Genes de resistencia presentes en bacterias productoras de carbapenemasas en el Hospital Vicente Corral Moscoso, Cuenca. 2017-2018

Abstract

INTRODUCTION: Genes acquire different molecular resistance mechanisms through mutations at the chromosomal level or horizontal transfer of genetic material between bacteria of the same or different species. Knowing the mechanisms of bacterial resistance and the genes involved will allow us to optimize epidemiological surveillance, control policies and antibiotic use worldwide.GENERAL OBJECTIVE: To establish the resistance genes present in carbapenemase producing bacteria in the Vicente CorralMoscoso Hospital, Cuenca. 2017-2018.METHODOLOGY: The study was descriptive, retrospective and cross sectional. The reports were analyzed based on results of positive cultures forbacteria that presented resistance to at least one carbapenem in the microbiology area of the HVCMand the resistance gene confirmed by the INSPI-RAM-CUENCA.RESULTS: Of the 100,00% of resistancegenes present in carbapenemase producing bacteria, 56,58% corresponded to the male sex because it wasthe most vulnerable to bacterial infections. The 70-79 year old age group presented 16,95% of resistance genesreports, with the purulent secretion sample being the most identified with 44,92%. The Clinic's hospital service reported 51,70% of strains, with Klebsiella pneumoniaeproducing carbapenemase type KPC prevailing in 71,18% of the total reports.CONCLUSION:The genof frequent resistance in HVCM was blaKPC, identified in male patients of the third age. The main bacterial genus/species was Klebsiella pneumoniae.