Seguridad y eficacia del cenobamato como coadyuvante en el tratamiento de la epilepsia focal

Abstract

Epilepsy is a disorder in which the activity of nerve cells in the brain is interrupted, manifesting with recurrent seizures that are classified into localized and focal seizures, therefore focal epilepsy will be analyzed, which is a chronic neurological condition that affects the quality of life of millions of people in the world. Despite advances in the development of pharmacological treatments, approximately a quarter of patients do not respond adequately to conventional antiepileptic drugs. Consequently, the safety and efficacy of cenobamate as an adjunctive treatment in patients with focal epilepsy is evaluated through a literature review with eight clinical trials classified as high quality studies according to the CONSORT Guide, which showed cenobamate to be safe and effective for the treatment of focal epilepsy compared to a concomitant drug and a placebo, dizziness, somnolence and fatigue being the most common and unavoidable adverse events and with an efficacy rate of more than 50% in terms of seizure reduction.