Parámetros hematológicos y su relación con el pronóstico de caninos afectados por variantes del Protoparvovirus carnivoro 1

Abstract

Canine parvovirus is a major infectious disease affecting young dogs, and is still a viral disease with significant morbidity and mortality in worldwide. However, it is currently unclear which physiological parameters or variables can help define the prognosis of affected patients. Therefore, the present study aimed to analyze the relationship between canine (Canis lupus familiaris) hematological parameters, the viral variant of Canine parvovirus 2 (CPV-2), a subspecies of Carnivorous protoparvovirus 1 (CPPV-1) involved in the infection, and the outcome of patients affected by Canine parvovirus. For the above, 49 blood samples and rectal swabs were collected from canine patients affected by Canine parvovirosis, who underwent a complete blood count. The total DNA samples obtained from the rectal swabs were validated using a PCR assay, in the same way the detection of CPV-2 DNA, and an ARMS-PCR was used to identify the viral variant. As a result, it was found that in the canines included in the study, more than half had low values of leukocytes, neutrophils, hemoglobin and hematocrit, and less frequently high values of the percentages of lymphocytes and basophils. The infection was confirmed in 47 canines in which the three CPV-2 variants were identified; with 41,9 % of the 2a variant, 27,9 % of the 2b and 30,2 % of the 2c. In the study group, 58,1 % of dogs died, primarily those infected with the 2c variant, followed by those affected by the 2b variant. Finally, death was common in dogs just one or two months old, more pronounced in unvaccinated patients, and with slightly lower red cell counts and higher white cell counts.