Efecto de la administración de aceite de cáñamo Cannabis sativa (CBD) sobre el índice fagocítico en perros domésticos Canis lupus familiaris

Abstract

The aim of this study was to evaluate the modulatory effect of hemp essential oil CBD, derived from Cannabis sativa, on the phagocytosis index (FI) in domestic dogs (Canis lupus familiaris). Twenty dogs were studied, distributed among females, males, adults and geronts: the dogs received CBD orally at a rate of 2.5 mg/kg/12h for 21 days. Phagocytic cells and IF were determined at three times during the study (day 0, day 10, day 21). The variance of the data was analyzed using Student's t-test for paired and independent samples and chi-squared test to determine the association between IF values and the independent variables sex and age. Highly significant differences were obtained in the phagocytic cells of activated and inactivated serum. There was no significant difference in IF between adult dogs vs. geronts; and females vs. males. The administration of CBD significantly reduces the activity of phagocytic cells in peripheral blood of dogs, the IF did not present changes, since the activity of CBD reduces phagocytic cells both in those cultured in activated and inactivated serum; as for the age and sex factors, it was considered that these factors do not interfere with CBD in relation to the modulation of phagocytosis through pathways independent of complement activation and/or the reduction in the expression of receptors for opsonins.