Plants and natural products with activity against various types of coronaviruses: a review with focus on SARS-CoV-2
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Date
2021
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Abstract
COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Natural products that mitigate the symptoms caused by various coronaviruses are also presented. Particular attention was placed on natural products that stabilize the Renin–Angiotensin–Aldosterone System (RAAS), which has been associated with the entry of the SARS-CoV-2 into human cells.
Resumen
COVID-19 es una enfermedad pandémica causada por el virus SARS-CoV-2, que es potencialmente fatal para las personas vulnerables. El manejo de la enfermedad representa un desafío para muchos países, dada la escasez de medicamentos y recursos hospitalarios. El objetivo de este trabajo fue revisar las plantas medicinales, alimentos y productos naturales que presentan evidencia científica para la protección del huésped frente a diversos tipos de coronavirus, con foco en el SARS-CoV-2. También se presentan productos naturales que atenúan los síntomas provocados por diversos coronavirus. Se prestó especial atención a los productos naturales que estabilizan el Sistema Renina-Angiotensina-Aldosterona (RAAS), que se ha asociado con la entrada del SARS-CoV-2 en las células humanas.
Keywords
Middle east respiratory syndrome, Severe acute respiratory syndrome coronavirus, COVID-19, Medicinal plants, Antiviral, Biomolecules