Prevalencia de los tipos moleculares de cáncer de mama y características clínico-patológicas, SOLCA, Cuenca, agosto 2010 – julio 2017

Abstract

Background: Breast cancer, according to the WHO, is the most common cancer in women worldwide, and in Ecuador it has an incidence of 30 cases per 100,000 inhabitants per year. Historically, it was classified according to clinical characteristics, stage and tumor grade. The molecular classification is used in the diagnosis of challenging lesions and to differentiate the subtypes of lesions, with prognostic character. Main Objective: To determine the prevalence of molecular types of breast cancer and its clinical-pathological characteristics in patients of “Instituto del Cáncer SOLCA – Cuenca” in the period August 2010 - July 2017. Method and Materials: Analytical and cross-sectional study. 582 clinical records that met the selection criteria were analyzed. The information obtained from the database of “Instituto del Cáncer SOLCA”, and extrapolated to the collection form. The software SPSS 19.0 was used for its analysis. Results: The most prevalent molecular type is Luminal A (35.22%), its predominant histological type is ductal (92.96%), increasing its prevalence after the age of 40 years old (92,26%). The clinical stage with the highest prevalence is IIA (29.21%) and according to Nottingham score, 76.80% was grade III. Conclusions: The molecular types of breast cancer are statistically associated with the clinical characteristics: age and family pathological background; and the pathological characteristics: histological type, Nottingham score and clinical stage.