Revisión bibliográfica de los efectos de los suplementos probióticos sobre los parámetros bioquímicos relacionados con la glucosa y los lípidos en pacientes con diabetes mellitus tipo 2

Abstract

DM2 is an endocrine-metabolic disease characterized by chronic hyperglycemia. Probiotics have become a novel therapeutic modality for the control and/or prevention of DM2 through the modulation of the intestinal microbiota. The objective of this review was to determine the effect of probiotic supplements on biochemical parameters of glucose and lipids in patients with DM2 through a literature review. The databases used are PubMed, ScienceDirect, and Scopus to search for clinical trials that have examined the effects of probiotic supplementation on basal glucose parameters, HbA1c, basal insulin, HOMA-IR index, TC, TG, C -HDL, and LDL-C in patients with DM2. The quality of the selected articles was evaluated using the “PEDRO” scale. The results of this review indicate that most part of the scientific evidence reports a significant decrease until -37.16 mg/dl of basal glucose, - 0.65% HbA1c, and - 24.36 mg/dl of TC after the intake of probiotics, especially of the genera Lactobacillus and bifidobacterium. There are not enough clinical trials that report positive changes in TG and HDL-C, in addition, the changes in basal insulin concentrations, HOMAIR index, and LDL-C are not entirely conclusive. Our review suggests that taking probiotics is beneficial and could be a complementary therapeutic approach in patients with DM2.