Person:
Ochoa Avilés, Angélica María

Birth Date

1983-01-23

ORCID

0000-0001-7926-3644

Scopus Author ID

55385603500

Afiliación

Universidad de Cuenca, Cuenca, Ecuador
Universidad de Cuenca, Departamento de Biociencias, Cuenca, Ecuador
Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador

País

Ecuador

Organizational Units

Organizational Unit

Facultad de Ciencias Químicas

Fundada en 1955 como la Escuela de Química Industrial, la facultad ha sido un pilar fundamental en la formación de profesionales altamente capacitados, comprometidos con el desarrollo de la ciencia, la educación y el bienestar social. La Facultad de Ciencias Químicas pone a consideración su trabajo académico, investigativo y de vinculación con la sociedad, desarrollado a través de la práctica de una docencia de calidad, investigación e innovación en su área de estudio. Desde su oficio de conocimiento se permite contribuir a la sociedad con cuatro carreras: Bioquímica y Farmacia, Ingeniería Química, Ingeniería Ambiental e Ingeniería Industrial. Su carta de presentación en la Academia, la coloca como una dependencia dinámica, donde confluye la solidez de una trayectoria de más de sesenta años. Aquí se trabaja en una continua formación de pregrado y posgrado de la más alta calidad, mediante la mejora continua con la innovación y a la vanguardia de las ciencias químicas.

Job Title

Profesor (T)

Last Name

Ochoa Avilés

First Name

Angélica María

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Prevalence and socioeconomic differences of risk factors of cardiovascular disease in Ecuadorian adolescents
(2012) Ochoa Avilés, Angélica María; Andrade Tenesaca, Dolores Susana; Donoso Moscoso, Silvana Patricia; Huynh, Thi Thanh Tuyen; Verstraeten, Roosmarijn; Lachat, Carl; Rojas Alvarado, Rosendo Andres; Manuel Keenoy, Begoña; Kolsteren, Patrick
Purpose: The aim of this paper is to report the prevalence of cardiovascular risk factors and socioeconomic differences in school-going Ecuadorian adolescents. Methods: A cross-sectional study was performed from January 2008 until April 2009 in 770 adolescents aged 10 to 16 years old, who attend secondary schools in an urban (Cuenca), and rural area (Nabón) in Ecuador. Data collected for the overall sample included anthropometric variables (weight, height and waist circumference), blood pressure and socio-demographic characteristics. Fasting blood glucose and lipid profile determinations were collected in a subsample of 334 adolescents. Results: The most prevalent cardiovascular risk factors were dyslipidemia (34.2%), abdominal obesity (19.7%) and overweight (18.0%). The prevalence of the remaining cardiovascular risk factors were high levels of blood pressure (6.2%) and obesity (2.1%). Boys were 3.3 times (P < 0.001) more likely to have risk levels of blood pressure. Compared to their peers from lower socioeconomic groups, children from better off socioeconomic strata were 1.5 times (P = 0.048) more likely to be overweight/obese and 1.5 times (P = 0.046) more likely to have abdominal obesity. Overweight and obese children were 4.4 times more likely to have dyslipidemia (P < 0.001). Children living in the rural area were 2.8 times (P = 0.002) more likely to have dyslipidemia than those from the urban area. Conclusions: Our results demonstrate the advanced levels of the nutrition transition in this Ecuadorian adolescent population. Primary health care should monitor and take actions to address this public health problem in adolescents.
Revisión sistemática de estudios sobre inocuidad alimentaria en Cuenca, Ecuador, periodo 1981-2017
(2020) Ortiz Ulloa, Silvia Johana; Castro Arteaga, Evelyn Michelle; Ochoa Avilés, Angélica María; Donoso Moscoso, Silvana Patricia
Objetivo: Evaluar la evidencia existente sobre inocuidad alimentaria en el cantón Cuenca, Ecuador. Materiales y métodos: Se realizó una revisión sistemática de los estudios en inocuidad alimentaria (microorganismos, contaminantes y adulterantes) durante el período 1981-2017. Resultados: Inicialmente se identificaron 640 estudios. Luego del análisis de los criterios de inclusión y exclusión, se incluyeron 40 estudios relacionados a evaluaciones microbiológicas (67.5%), pesticidas, parásitos y antibióticos (7.5%), conservantes y metales (10%) y toxinas (15%). Discusión: En los estudios se recalca la necesidad de implementar medidas de higiene y monitoreo, control en la manipulación, transporte y almacenamiento, control de los alimentos frescos cuya calidad no está regida por normativas nacionales, capacitar a los manipuladores y vendedores ambulantes. Esta revisión proporciona una base racional para toma de decisiones y desarrollo de medidas preventivas y correctivas; así como también propone los criterios mínimos de muestreo y análisis para discriminar y comparar estudios en esta problemática.
Two years of school-based intervention program could improve the physical fitness among Ecuadorian adolescents at health risk: Subgroups analysis from a cluster-randomized trial
(2016) Andrade Tenesaca, Dolores Susana; Ochoa Avilés, Angélica María; Donoso Moscoso, Silvana Patricia; Ortiz Ulloa, Silvia Johana
Background Adolescents with overweight and poor physical fitness have an increased likelihood of developing cardiovascular diseases during adulthood. In Ecuador, a health promotion program improved the muscular strength and speed-agility, and reduced the decline of the moderate-to-vigorous physical activity of adolescents after 28 months. We performed a sub-group analysis to assess the differential effect of this intervention in overweight and low-fit adolescents. Methods We performed a cluster-randomized pair matched trial in schools located in Cuenca–Ecuador. In total 20 schools (clusters) were pair matched, and 1440 adolescents of grade 8 and 9 (mean age of 12.3 and 13.3 years respectively) participated in the trial. For the purposes of the subgroup analysis, the adolescents were classified into groups according to their weight status (body mass index) and aerobic capacity (scores in the 20 m shuttle run and FITNESSGRAM standards) at baseline. Primary outcomes included physical fitness (vertical jump, speed shuttle run) and physical activity (proportion of students achieving over 60 min of moderate–to-vigorous physical activity/day). For these primary outcomes, we stratified analysis by weight (underweight, normal BMI and overweight/obese) and fitness (fit and low fitness) groups. Mixed linear regression models were used to assess the intervention effect. Results The prevalence of overweight/obesity, underweight and poor physical fitness was 20.3 %, 5.8 % and 84.8 % respectively. A higher intervention effect was observed for speed shuttle run in overweight (β = −1.85 s, P = 0.04) adolescents compared to underweight (β = −1.66 s, P = 0.5) or normal weight (β = −0.35 s, P = 0.6) peers. The intervention effect on vertical jump was higher in adolescents with poor physical fitness (β = 3.71 cm, P = 0.005) compared to their fit peers (β = 1.28 cm, P = 0.4). The proportion of students achieving over 60 min of moderate-to-vigorous physical activity/day was not significantly different according to weight or fitness status. Conclusion Comprehensive school-based interventions that aim to improve diet and physical activity could improve speed and strength aspects of physical fitness in low-fit and overweight/obese adolescents.
Factors affecting physical activity in ecuadorian adolescents: a focus group study
(2015) Van Royen, Kathleen; Verstraeten, Roosmarijn; Andrade Tenesaca, Dolores Susana; Ochoa Avilés, Angélica María; Donoso Moscoso, Silvana Patricia; Maes, Lea; Kolsteren, Patrick
Background: Physical inactivity levels are increasingly prevalent among Ecuadorian adolescents. School-based interventions can be potentially effective in promoting physical activity but must be informed by cultural-specific factors. Methods: Twelve focus groups were carried out with adolescents (n = 80) in rural and urban Ecuador to identify factors influencing physical activity. In addition, 4 focus group discussions with parents (n = 32) and 4 with school staff (n = 32) were conducted. Individual and environmental factors were questioned using the ‘Attitude, Social influences and Self-efficacy’ model and the socioecological model as theoretical frameworks. Results: Factors influencing physical activity varied between groups. In the rural area farming and norms for girls impeded leisure-time physical activity, whereas urban groups emphasized traffic and crime concerns. Groups from a low socioeconomic status more frequently mentioned a fear of injuries and financial constraints. Several factors were common for all groups including preferences for sedentary activities, poor knowledge, time constraints and laziness, as well as a lack of opportunities at home and school, unsupportive parental rules and lack of role models. Conclusion: A conceptual framework including the identified factors emerged to inform the design of a cultural-sensitive school-based intervention to improve physical activity among Ecuadorian adolescents. Future interventions should be tailored to each setting.
Physical fitness among urban and rural ecuadorian adolescents and its association with blood lipids: a cross sectional study
(2014) Ochoa Avilés, Angélica María; Lachat, Carl K.; Andrade Tenesaca, Dolores Susana; Kolsteren, Patrick Wilfried; Cardon, Greet Maria; Rojas Reyes, Rosendo Ivan; Donoso Moscoso, Silvana Patricia; Van Camp, John Hendrik; Verstraeten, Roosmarijn
Background: Physical fitness has been proposed as a marker for health during adolescence. Currently, little is known about physical fitness and its association with blood lipid profile in adolescents from low and middle-income countries. The aim of this study is therefore to assess physical fitness among urban and rural adolescents and its associations with blood lipid profile in a middle-income country. Methods: A cross-sectional study was conducted between January 2008 and April 2009 in 648 Ecuadorian adolescents (52.3% boys), aged 11 to 15 years, attending secondary schools in Cuenca (urban n = 490) and Nabón (rural n = 158). Data collection included anthropometric measures, application of the EUROFIT battery, dietary intake (2-day 24 h recall), socio-demographic characteristics, and blood samples from a subsample (n = 301). The FITNESGRAM standards were used to evaluate fitness. The associations of fitness and residential location with blood lipid profile were assessed by linear and logistic regression after adjusting for confounding factors. Results: The majority (59%) of the adolescents exhibited low levels of aerobic capacity as defined by the FITNESSGRAM standards. Urban adolescents had significantly higher mean scores in five EUROFIT tests (20 m shuttle, speed shuttle run, plate tapping, sit-up and vertical jump) and significantly most favorable improved plasma lipid profile (triglycerides and HDL) as compared to rural adolescents. There was a weak association between blood lipid profile and physical fitness in both urban and rural adolescents, even after adjustment for confounding factors. Conclusions: Physical fitness, in our sample of Ecuadorian adolescents, was generally poor. Urban adolescents had better physical fitness and blood lipid profiles than rural adolescents. The differences in fitness did not explain those in blood lipid profile between urban and rural adolescents.
A school-based intervention improves physical fitness in Ecuadorian adolescents: a cluster-randomized controlled trial
(2014) Andrade Tenesaca, Dolores Susana; Ochoa Avilés, Angélica María; Andrade Muñoz, Diana Jesús; Rojas Reyes, Rosendo Iván; Donoso Moscoso, Silvana Patricia; Kolsteren, Patrick
Background: Effective lifestyle interventions are needed to prevent noncommunicable diseases in low- and middle-income countries. We analyzed the effects of a school-based health promotion intervention on physical fitness after 28 months and explored if the effect varied with important school characteristics. We also assessed effects on screen time, physical activity and BMI. Methods and results: We performed a cluster-randomized pair matched trial in schools in urban Ecuador. The intervention included an individual and environmental component tailored to the local context and resources. Primary outcomes were physical fitness (EUROFIT battery), screen time (questionnaires) and physical activity (accelerometers). Change in BMI was a secondary outcome. A total of 1440 grade 8 and 9 adolescents (intervention: n = 700, 48.6%) and 20 schools (intervention: n = 10, 50%) participated. Data of 1083 adolescents (intervention: n = 550, 50.8%) from 20 schools were analyzed. The intervention increased vertical jump (mean effect 2.5 cm; 95% CI 0.8-4.2; P = 0.01). Marginally insignificant, adolescents from the intervention group needed less time for speed shuttle run (intervention effect = −0.8 s, 95% CI −1.58-0.07; P = 0.05). The proportion of students achieving over 60 minutes of moderate-to-vigorous physical activity/day decreased over time with the change in proportion significantly less in the intervention schools (6 vs. 18 percentage points, P < 0.01). The intervention effect on speed shuttle run was significant in larger schools while the effect on vertical jump was larger in mixed gender school compared to small and female schools. The proportion of schools that met the recommendations for physical activity increased with 37% in intervention schools with half-day schedule compared to the controls in the pair. No significant effects were found on screen time and BMI. Measurement of physical activity in a subsample was a limitation. No adverse effects were reported. Conclusions: A school-based intervention with an individual and environment component can improve physical fitness and can minimize the decline in physical activity levels from childhood into adolescence in urban Ecuador.
Tabla de composición de alimentos Cuenca, Ecuador
(Universidad de Cuenca, 2018) Ortiz Ulloa, Silvia Johana; Astudillo Rubio, Gabriela Cristina; Donoso Moscoso, Silvana Patricia; Ochoa Avilés, Angélica María; Ortiz Ulloa, Silvia Johana; Donoso Moscoso, Silvana Patricia; Ochoa Avilés, Angélica María
The designations employed and the presentation of this material do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) concerning the legal or development status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or products of manufacturers, whether or not these have been patented, does not imply that these have been endorsed or recommended by FAO in preference to others of a similar nature that are not mentioned. The views expressed in this information product are those of the author(s) and do not necessarily reflect the views of FAO.
Dietary intake practices associated with cardiovascular risk in urban and rural Ecuadorian adolescents: A cross-sectional study
(2014) Ochoa Avilés, Angélica María; Verstraeten, Roosmarijn; Lachat, Carl; Andrade Tenesaca, Dolores Susana; Van Camp, John; Donoso Moscoso, Silvana Patricia; Kolsteren, Patrick
Background: Cardiovascular diseases (CVD) are amongst the leading causes of death worldwide. Risk factors of CVD develop during childhood and adolescence, and dietary quality has been linked to the development of CVD itself. This study examines the association between dietary patterns and cardiovascular risk in a group of urban and rural Ecuadorian adolescents from different socioeconomic backgrounds. Methods. A cross-sectional study was conducted from January 2008 to April 2009 among 606 adolescents from the 8th, 9th and 10th grade in an urban area (Cuenca), and 173 adolescents from a rural area (Nabón) in Ecuador. Data collection involved measuring anthropometric data (weight, height and waist circumference), blood pressure, dietary intake (2-day 24 h recall) and socio-demographic characteristics. Fasting blood lipids and glucose were measured in a subsample of 334 adolescents. Factor analysis was used to identify dietary patterns and linear regression models were used to (i) identify differences in food intake practices according to socioeconomic status and place of residence and (ii) establish relationships between dietary patterns and cardiovascular risk factors. Results: Median energy intake was 1851 kcal/day. Overall, fiber, fish and fruit and vegetables were scarcely consumed, while added sugar, refined cereals and processed food were important constituents of the diet. Two dietary patterns emerged, one labelled as rice-rich non-animal fat pattern and the other one as wheat-dense animal-fat pattern. The first pattern was correlated with a moderate increase in glucose in urban participants, while the second pattern was associated with higher LDL and cholesterol blood levels in rural participants. Conclusions: This group of adolescents presented various dietary practices conducive to CVD development. Effective strategies are needed to prevent CVD in the Ecuadorian population by encouraging a balanced diet, which contains less refined cereals, added sugar, and processed food, but has more fruits, vegetables and whole grain cereals.
Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys
(2020) Miranda, Jaime J; Carrillo Larco, Rodrigo M; Ferreccio, Catterina; Hambleton, Ian R; Bentham, James; Lotufo, Paulo A; Bixby, Honor; Taddei, Cristina; Andrade Tenesaca, Dolores Susana; Bernabe Ortiz, Antonio; Bettiol, Heloisa; Boggia de Izaguirre, josé Gabriel; Donoso Moscoso, Silvana Patricia; Ochoa Avilés, Angélica María; Di Cesare, Mariachiara; Nieto Martínez, Ramfis; Bin, Zhou; Hajifathalian, Kaveh; Abarca Gómez, Leandra; Acosta Cazares, Benjamin; Aguilar Salinas, Carlos A.; Assuncao , Maria Cecília F.; Barceló, Alberto; Dornellas de Barros, Aluísio Jardim; Gomes de Barros, Mauro Virgilio; Bata, Iqbal; Batista, Rosangela L; Brewster, Lizzy M; Cardoso, Viviane C; Chan, Queenie; Destro Christofaro, Diego Giulliano
Background Describing the prevalence and trends of cardiometabolic risk factors that are associated with noncommunicable diseases (NCDs) is crucial for monitoring progress, planning prevention, and providing evidence to support policy efforts. We aimed to analyse the transition in body-mass index (BMI), obesity, blood pressure, raised blood pressure, and diabetes in the Americas, between 1980 and 2014. Methods We did a pooled analysis of population-based studies with data on anthropometric measurements, biomarkers for diabetes, and blood pressure from adults aged 18 years or older. A Bayesian model was used to estimate trends in BMI, raised blood pressure (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg), and diabetes (fasting plasma glucose ≥7·0 mmol/L, history of diabetes, or diabetes treatment) from 1980 to 2014, in 37 countries and six subregions of the Americas. Findings 389 population-based surveys from the Americas were available. Comparing prevalence estimates from 2014 with those of 1980, in the non-English speaking Caribbean subregion, the prevalence of obesity increased from 3·9% (95% CI 2·2–6·3) in 1980, to 18·6% (14·3–23·3) in 2014, in men; and from 12·2% (8·2–17·0) in 1980, to 30·5% (25·7–35·5) in 2014, in women. The English-speaking Caribbean subregion had the largest increase in the prevalence of diabetes, from 5·2% (2·1–10·4) in men and 6·4% (2·6–10·4) in women in 1980, to 11·1% (6·4–17·3) in men and 13·6% (8·2–21·0) in women in 2014). Conversely, the prevalence of raised blood pressure has decreased in all subregions; the largest decrease was found in North America from 27·6% (22·3–33·2) in men and 19·9% (15·8–24·4) in women in 1980, to 15·5% (11·1–20·9) in men and 10·7% (7·7–14·5) in women in 2014. Interpretation Despite the generally high prevalence of cardiometabolic risk factors across the Americas, estimates also showed a high level of heterogeneity in the transition between countries. The increasing prevalence of obesity and diabetes observed over time requires appropriate measures to deal with these public health challenges. Our results support a diversification of health interventions across subregions and countrie
Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
(2015) Danaei, Goodarz; Ochoa Avilés, Angélica María; Ezzati, Majid; Andrade Tenesaca, Dolores Susana; Zheng, Yao
Background Diabetes has been defi ned on the basis of diff erent biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the eff ect of diff erent diagnostic defi nitions on both the population prevalence of diabetes and the classifi cation of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in diff erent regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defi ning diabetes. Diabetes was defi ned using HbA1c (HbA1c ≥6·5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT defi nitions (FPG ≥7·0 mmol/L or 2hOGTT ≥11·1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using diff erent defi nitions graphically and by regression analyses. We calculated sensitivity and specifi city of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specifi city in each survey, and then pooled results using a random-eff ects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG-or-2hOGTT was correlated with prevalence based on FPG alone (r=0·98), but was higher by 2–6 percentage points at diff erent prevalence levels. Prevalence based on HbA1c was lower than prevalence based on FPG in 42·8% of age–sex–survey groups and higher in another 41·6%; in the other 15·6%, the two defi nitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA1c-based prevalences was partly related to participants’ age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specifi c communities. Diabetes defi ned as HbA1c 6·5% or more had a pooled sensitivity of 52·8% (95% CI 51·3–54·3%) and a pooled specifi city of 99·74% (99·71–99·78%) compared with FPG 7·0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defi ned based on FPGor-2hOGTT was 30·5% (28·7–32·3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA1c versus FPG. Interpretation Diff erent biomarkers and defi nitions for diabetes can provide diff erent estimates of population prevalence of diabetes, and diff erentially identify people without previous diagnosis as having diabetes. Using an HbA1c-based defi nition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test.