Browsing by Author "Moreno Robalino, Andrea Alejandra"

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Deontología odontológica. Quo vadis
(Universidad de Cuenca, 2018) Álvarez Vásquez, José Luis; Moreno Robalino, Andrea Alejandra
Determinants of the Number of Main Canals in a Tooth: Deciphering Potential Mechanisms
(2023) Álvarez Vásquez, José Luis; Moreno Robalino, Andrea Alejandra
Background: Although millions of root canal treatments are performed globally on a daily basis, factors that determine the number of main root canals in a tooth have not yet been elucidated. Variations in the number of root canals in different teeth is of utmost importance in clinical practice. However, clinicians aren´t aware about the determinants of such number, let alone these determinants have been approached in the literature, to the best of our knowledge. Purpose: This narrative review aimed to integrate the potential mechanisms involved in determining the number of main canals in a permanent tooth. Methods: We used the search terms “root canal number,” “root canal morphology,” “tooth morphology,” “root development,” and “root formation” to identify articles from the PubMed and Scopus databases. Results: 57 articles and 2 books were obtained. A multifactorial basis is plausible considering the influence of anthropological, demographic, environmental, genetic, epigenetic, tooth size related mechanisms and the pivotal role of Hertwig’s epithelial root sheath. Live-cell imaging techniques, mathematical models, quantitative genetics and dental phenomics could provide insightful information in the near future. Conclusions: Overall, it seems that the potential mechanisms determining the number of main canals in a tooth have a multifactorial basis. The orchestrating role of the Hertwig's epithelial root sheath seem pivotal, although the speciﬁc regulatory signals that induce or repress its diaphragmatic processes remain unknown. However, there is a dire need for molecular studies that help unveil these and other potential mechanisms involved.
Number of main canals in a tooth: deciphering potential mechanisms.
(Universidad de Cuenca, 2022-10-21) Moreno Robalino, Andrea Alejandra; Álvarez Vásquez, José Luis
Although millions of root canal treatments are performed globally on a daily basis, factors that determine the number of main root canals in a tooth have not yet been elucidated. This review aimed to integrate the potential mechanisms involved in determining the number of main canals in a permanent tooth. Methods: We used the search terms “root canal number,” “root canal morphology,” “tooth morphology,” “root development,” and “root formation” to identify articles from the PubMed and Scopus databases. Results: Overall, it seems plausible that the potential mechanisms determining the number of main canals in a tooth are based on the orchestrating role of the Hertwig's epithelial root sheath in root development, although the specific molecular signals that govern the induction or repression of the diaphragmatic processes remain unknown. A multifactorial basis is possible considering the influence of genetic, epigenetic, and environmental factors. Conclusions: This review highlights potential mechanisms determining the number of main canals in a tooth; however, there is a dire need for molecular studies that help unveil these and other potential mechanisms involved.