Browsing by Author "Hesdorffer, Dale C."

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    Comment on epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    (2005-10) Beghi, Ettore; Carpio, Arturo; Berg, Anne; Forsgren, Lars; Hesdorffer, Dale C.; Hauser, W. Allen; Malmgren, Kristina; Shinnar, Shlomo; Temkin, Nancy; Thurman, David; Tomson, Torbjörn
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    Investigation of familial aggregation of seizures in neurocysticercosis patients
    (2009-03) Kelvin, Elizabeth A.; Carpio, Arturo; Bagiella, Emilia; Leslie, Denise; León, Pedro; Howard, Andrews; Hauser, W. Allen; Hesdorffer, Dale C.
    Regional differences in the clinical manifestations of human neurocysticercosis (NCC) may indicate a role of host genetics. We examined whether there is familial aggregation of seizures in first-degree relatives of NCC patients with seizure versus NCC patients without seizure as presenting symptom in a group of patients in Ecuador. The results of our analyses were null, and there was no trend toward familial aggregation of seizures in NCC patients.
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    Recommendation for a definition of acute symptomatic seizure
    (2010-04) Beghi, Ettore; Carpio, Arturo; Forsgren, Lars; Hesdorffer, Dale C.; Malmgren, Kristina; Sander, Josemir W. A. S.; Tomson, Torbjörn; Hauser, W. Allen
    PURPOSE: To consider the definition of acute symptomatic seizures for epidemiological studies, and to refine the criteria used to distinguish these seizures from unprovoked seizures for specific etiologies. METHODS: Systematic review of the literature and of epidemiologic studies. RESULTS: An acute symptomatic seizure is defined as a clinical seizure occurring at the time of a systemic insult or in close temporal association with a documented brain insult. Suggestions are made to define acute symptomatic seizures as those events occurring within 1 week of stroke, traumatic brain injury, anoxic encephalopathy, or intracranial surgery; at first identification of subdural hematoma; at the presence of an active central nervous system (CNS) infection; or during an active phase of multiple sclerosis or other autoimmune diseases. In addition, a diagnosis of acute symptomatic seizure should be made in the presence of severe metabolic derangements (documented within 24 h by specific biochemical or hematologic abnormalities), drug or alcohol intoxication and withdrawal, or exposure to well-defined epileptogenic drugs. DISCUSSION: Acute symptomatic seizures must be distinguished from unprovoked seizures and separately categorized for epidemiologic purposes. These recommendations are based upon the best available data at the time of this report. Systematic studies should be undertaken to better define the associations in question, with special reference to metabolic and toxic insults, for which the time window for the occurrence of an acute symptomatic seizure and the absolute values for toxic and metabolic dysfunction still require a clear identification.
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    The primary prevention of epilepsy: a report of the prevention task force of the international league against epilepsy
    (2018) Thurman, David J.; Carpio Rodas, Luis Arturo; Hesdorffer, Dale C.; Newton, Charles Richard
    Among the causes of epilepsy are several that are currently preventable. In this review, we summarize the public health burden of epilepsy arising from such causes and suggest priorities for primary epilepsy prevention. We conducted a systematic review of published epidemiologic studies of epilepsy of 4 preventable etiologic categories—perinatal insults, traumatic brain injury (TBI), central nervous system (CNS) infection, and stroke. Applying consistent criteria, we assessed the quality of each study and extracted data on measures of risk from those with adequate quality ratings, summarizing findings across studies as medians and interquartile ranges. Among higher‐quality population‐based studies, the median prevalence of active epilepsy across all ages was 11.1 per 1000 population in lower‐ and middle‐income countries (LMIC) and 7.0 per 1000 in high‐income countries (HIC) …