Browsing by Author "Garcia Contreras, Consolación"

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    The impact of prenatal environment on postnatal life and performance: future perspectives for prevention and treatment
    (2020) González Bulnes, Antonio; Parraguez, Víctor Hugo; Berlinguer, Fiammetta; Barbero Fernández, Alicia; Garcia Contreras, Consolación; López Tello, Jorge; Pesántez Pacheco, José Luis; Martínez Ros, Paula
    The present review aims to offer a non-comprehensive outline of the current state-of-the-art and future perspectives on management and therapeutic tools for intrauterine growth restriction (IUGR) and associated prenatal programming in both human and animal species. Animals are used as models for the study of phenomena related to IUGR, but also for research on prenatal therapies with the main objective of designing and developing preventive and therapeutic strategies. The research is currently paying attention on maternal-focused pharmacological treatments and nutritional strategies but also on fetal-focused treatments. Fetal-focused treatments, administered either directly at the fetus or by using infusion of umbilical cord, amniotic sac or placenta, which avoids the administration of substances at high doses to the mother for allowing their availability at the fetoplacental level. The results obtained in this area of research using large animals (rabbits, pigs and ruminants) have a dual interest, for translational biomedicine and for veterinary medicine and animal production.
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    The role of offspring genotype-by-sex interactions, independently of environmental cues, on the phenotype traits of an obese swine model
    (2020) González Bulnes, Antonio; Heras Molina, Ana; Pesántez Pacheco, José Luis; Astiz, Susana; Garcia Contreras, Consolación; Vázquez Gómez, Marta; Beatriz, Isabel; Ovilo, Cristina
    The present study aimed to assess the importance of offspring genotype on postnatal development, independently of confounding factors related to prenatal environment and postnatal lifestyle, using a translational model of obesity and metabolic syndrome (the Iberian pig). Hence, we compared two genotypes (purebred Iberian and crossbreds Iberian × Large White), produced in one single maternal environment (pure Iberian mothers) through artificial insemination of Iberian sows with Iberian and Large White heterospermic semen and maintained in the same conditions during postnatal development. The results indicate that, under same pre-and postnatal environments, the interaction genotype-by-sex has a determinant role on offspring phenotype (i.e., growth and development, metabolic and antioxidant status and fatty acid composition of different tissues). These results may set the basis for future preclinical and clinical research on the differences in the metabolic phenotype among genotypes.