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dc.contributor.authorGarcía Contreras, Consolación
dc.contributor.authorVázquez Gómez, Marta
dc.contributor.authorBarbero Fernández, Alicia
dc.contributor.authorPesantez Pacheco, Jose Luis
dc.contributor.authorZinellu, Angelo
dc.contributor.authorBerlinguer, Fiammetta
dc.contributor.authorGonzález Añover, Pedro
dc.contributor.authorGonzález, Jorge Ernesto
dc.contributor.authorEncinas, Teresa
dc.contributor.authorTorres Rovira, Laura
dc.contributor.authorNuñez, Yolanda
dc.contributor.authorBallesteros, Jaime
dc.contributor.authorAyuso, Miriam
dc.contributor.authorAstiz, Susana
dc.contributor.authorIsabel, Beatriz
dc.contributor.authorGonzález Bulnes, Antonio
dc.date.accessioned2019-08-07T20:15:17Z-
dc.date.available2019-08-07T20:15:17Z-
dc.date.issued2019
dc.identifier.issn1661-6596, 1422-0067 (e)
dc.identifier.urihttp://dspace.ucuenca.edu.ec/handle/123456789/33316-
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85062873820&doi=10.3390%2fijms20051187&origin=inward&txGid=341173c5c469de73a64c196cbdacfac2
dc.descriptionThe use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractThe use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoes_ES
dc.sourceInternational Journal of Molecular Sciences
dc.subjectAntioxidants
dc.subjectIntrauterine-Growth-Restriction
dc.subjectPregnancy
dc.subjectSwine-Model
dc.titlePolyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype
dc.title.alternative
dc.typeARTÍCULO
dc.ucuenca.idautorSgrp-1902-1
dc.ucuenca.idautor0000-0002-8916-2086
dc.ucuenca.idautorSgrp-1902 -3
dc.ucuenca.idautor0104911193
dc.ucuenca.idautor0000-0002-8396-0968
dc.ucuenca.idautor0000-0002-2500-8063
dc.ucuenca.idautorSgrp-1902 -7
dc.ucuenca.idautorSgrp-1902 -8
dc.ucuenca.idautorSgrp-1902 -9
dc.ucuenca.idautor0000-0003-1467-7533
dc.ucuenca.idautorSgrp-1902 -11
dc.ucuenca.idautorSgrp-1902 -12
dc.ucuenca.idautor0000-0001-6045-394x
dc.ucuenca.idautor0000-0002-9718-0903
dc.ucuenca.idautorSgrp-1902 -15
dc.ucuenca.idautor0000-0002-0917-4475
dc.identifier.doi10.3390/ijms20051187
dc.ucuenca.versionVersión publicada
dc.ucuenca.areaconocimientounescoamplio09 - Salud y Bienestar
dc.ucuenca.afiliacionGarcía, C., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionVázquez, M., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionBarbero, A., Universidad Alfonso X El Sabio (Madrid), Madrid, España
dc.ucuenca.afiliacionPesantez, J., Universidad de Cuenca, Facultad de Ciencias Agropecuarias, Cuenca, Ecuador
dc.ucuenca.afiliacionZinellu, A., Universitá degli Studi di Sassari (Sassari), Sassari, Italia
dc.ucuenca.afiliacionBerlinguer, F., Universitá degli Studi di Sassari (Sassari), Sassari, Italia
dc.ucuenca.afiliacionGonzález, P., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionGonzález, J., Center for Radiation Protection and Hygiene CPHR (Habana), Habana, Cuba
dc.ucuenca.afiliacionEncinas, T., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionTorres, L., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionNuñez, Y., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionBallesteros, J., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionAyuso, M., Universiteit Antwerpen (Antwerpen), Antwerpen, Belgica
dc.ucuenca.afiliacionAstiz, S., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionIsabel, B., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionGonzález, A., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.correspondenciaGonzález Bulnes, Antonio, bulnes@inia.es
dc.ucuenca.volumenvolumen 20, número 5
dc.ucuenca.indicebibliograficoSCOPUS
dc.ucuenca.factorimpacto1.312
dc.ucuenca.cuartilQ1
dc.ucuenca.numerocitaciones0
dc.ucuenca.areaconocimientofrascatiamplio3. Ciencias Médicas y de la Salud
dc.ucuenca.areaconocimientofrascatiespecifico3.1 Medicina Básica
dc.ucuenca.areaconocimientofrascatidetallado3.1.6 Química Medicinal
dc.ucuenca.areaconocimientounescoespecifico091 - Salud
dc.ucuenca.areaconocimientounescodetallado0912 - Medicina
dc.ucuenca.urifuentehttps://www.mdpi.com/1422-0067/20/1
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