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DC Field | Value | Language |
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dc.contributor.author | García Contreras, Consolación | - |
dc.contributor.author | Vázquez Gómez, Marta | - |
dc.contributor.author | Barbero Fernández, Alicia | - |
dc.contributor.author | Pesantez Pacheco, Jose Luis | - |
dc.contributor.author | Zinellu, Angelo | - |
dc.contributor.author | Berlinguer, Fiammetta | - |
dc.contributor.author | González Añover, Pedro | - |
dc.contributor.author | González, Jorge Ernesto | - |
dc.contributor.author | Encinas, Teresa | - |
dc.contributor.author | Torres Rovira, Laura | - |
dc.contributor.author | Nuñez, Yolanda | - |
dc.contributor.author | Ballesteros, Jaime | - |
dc.contributor.author | Ayuso, Miriam | - |
dc.contributor.author | Astiz, Susana | - |
dc.contributor.author | Isabel, Beatriz | - |
dc.contributor.author | González Bulnes, Antonio | - |
dc.date.accessioned | 2019-08-07T20:15:17Z | - |
dc.date.available | 2019-08-07T20:15:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1661-6596, 1422-0067 (e) | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85062873820&doi=10.3390%2fijms20051187&origin=inward&txGid=341173c5c469de73a64c196cbdacfac2 | - |
dc.description | The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.description.abstract | The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language.iso | es_ES | - |
dc.source | International Journal of Molecular Sciences | - |
dc.subject | Antioxidants | - |
dc.subject | Intrauterine-growth-restriction | - |
dc.subject | Pregnancy | - |
dc.subject | Swine-model | - |
dc.title | Polyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype | - |
dc.title.alternative | null | - |
dc.type | ARTÍCULO | - |
dc.ucuenca.idautor | Sgrp-1902-1 | - |
dc.ucuenca.idautor | 0000-0002-8916-2086 | - |
dc.ucuenca.idautor | 0000-0003-0213-6932 | - |
dc.ucuenca.idautor | 0104911193 | - |
dc.ucuenca.idautor | 0000-0002-8396-0968 | - |
dc.ucuenca.idautor | 0000-0002-2500-8063 | - |
dc.ucuenca.idautor | Sgrp-1902 -7 | - |
dc.ucuenca.idautor | Sgrp-1902 -8 | - |
dc.ucuenca.idautor | Sgrp-1902 -9 | - |
dc.ucuenca.idautor | 0000-0003-1467-7533 | - |
dc.ucuenca.idautor | Sgrp-1902 -11 | - |
dc.ucuenca.idautor | Sgrp-1902 -12 | - |
dc.ucuenca.idautor | 0000-0001-6045-394x | - |
dc.ucuenca.idautor | 0000-0002-9718-0903 | - |
dc.ucuenca.idautor | Sgrp-1902 -15 | - |
dc.ucuenca.idautor | 0000-0002-0917-4475 | - |
dc.identifier.doi | 10.3390/ijms20051187 | - |
dc.ucuenca.version | Versión publicada | - |
dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | - |
dc.ucuenca.afiliacion | García, C., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.afiliacion | Vázquez, M., Universidad Complutense de Madrid, Madrid, España | - |
dc.ucuenca.afiliacion | Barbero, A., Universidad Alfonso X El Sabio, Madrid, España | - |
dc.ucuenca.afiliacion | Pesantez, J., Universidad de Cuenca, Facultad de Ciencias Agropecuarias, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Zinellu, A., Universitá degli Studi di Sassari (Sassari), Sassari, Italia | - |
dc.ucuenca.afiliacion | Berlinguer, F., Universitá degli Studi di Sassari (Sassari), Sassari, Italia | - |
dc.ucuenca.afiliacion | González, P., Universidad Complutense de Madrid, Madrid, España | - |
dc.ucuenca.afiliacion | González, J., Center for Radiation Protection and Hygiene CPHR (Habana), Habana, Cuba | - |
dc.ucuenca.afiliacion | Encinas, T., Universidad Complutense de Madrid, Madrid, España | - |
dc.ucuenca.afiliacion | Torres, L., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.afiliacion | Nuñez, Y., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.afiliacion | Ballesteros, J., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.afiliacion | Ayuso, M., Universidad de Amberes (University of Antwerp), Amberes, Belgica | - |
dc.ucuenca.afiliacion | Astiz, S., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.afiliacion | Isabel, B., Universidad Complutense de Madrid, Madrid, España | - |
dc.ucuenca.afiliacion | González, A., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, España | - |
dc.ucuenca.correspondencia | González Bulnes, Antonio, bulnes@inia.es | - |
dc.ucuenca.volumen | Volumen 20, Número 5 | - |
dc.ucuenca.indicebibliografico | SCOPUS | - |
dc.ucuenca.factorimpacto | 1.312 | - |
dc.ucuenca.cuartil | Q1 | - |
dc.ucuenca.numerocitaciones | 0 | - |
dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | - |
dc.ucuenca.areaconocimientofrascatiespecifico | 3.1 Medicina Básica | - |
dc.ucuenca.areaconocimientofrascatidetallado | 3.1.6 Química Medicinal | - |
dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | - |
dc.ucuenca.areaconocimientounescodetallado | 0912 - Medicina | - |
dc.ucuenca.urifuente | https://www.mdpi.com/1422-0067/20/1 | - |
Appears in Collections: | Artículos |
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