Title: | Polyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype |
Other Titles: | |
Authors: | García Contreras, Consolación Vázquez Gómez, Marta Barbero Fernández, Alicia Pesantez Pacheco, Jose Luis Zinellu, Angelo Berlinguer, Fiammetta González Añover, Pedro González, Jorge Ernesto Encinas, Teresa Torres Rovira, Laura Nuñez, Yolanda Ballesteros, Jaime Ayuso, Miriam Astiz, Susana Isabel, Beatriz González Bulnes, Antonio |
metadata.dc.ucuenca.correspondencia: | González Bulnes, Antonio, bulnes@inia.es |
Keywords: | Antioxidants Intrauterine-growth-restriction Pregnancy Swine-model |
metadata.dc.ucuenca.areaconocimientofrascatiamplio: | 3. Ciencias Médicas y de la Salud |
metadata.dc.ucuenca.areaconocimientofrascatidetallado: | 3.1.6 Química Medicinal |
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: | 3.1 Medicina Básica |
metadata.dc.ucuenca.areaconocimientounescoamplio: | 09 - Salud y Bienestar |
metadata.dc.ucuenca.areaconocimientounescodetallado: | 0912 - Medicina |
metadata.dc.ucuenca.areaconocimientounescoespecifico: | 091 - Salud |
Issue Date: | 2019 |
metadata.dc.ucuenca.volumen: | Volumen 20, Número 5 |
metadata.dc.source: | International Journal of Molecular Sciences |
metadata.dc.identifier.doi: | 10.3390/ijms20051187 |
metadata.dc.type: | ARTÍCULO |
Abstract: | The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
Description: | The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85062873820&doi=10.3390%2fijms20051187&origin=inward&txGid=341173c5c469de73a64c196cbdacfac2 |
metadata.dc.ucuenca.urifuente: | https://www.mdpi.com/1422-0067/20/1 |
ISSN: | 1661-6596, 1422-0067 (e) |
Appears in Collections: | Artículos
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