Logo Repositorio Institucional

Por favor, use este identificador para citar o enlazar este ítem: http://dspace.ucuenca.edu.ec/handle/123456789/33316
Título : Polyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype
Otros títulos : 
Autor: García Contreras, Consolación
Vázquez Gómez, Marta
Barbero Fernández, Alicia
Pesantez Pacheco, Jose Luis
Zinellu, Angelo
Berlinguer, Fiammetta
González Añover, Pedro
González, Jorge Ernesto
Encinas, Teresa
Torres Rovira, Laura
Nuñez, Yolanda
Ballesteros, Jaime
Ayuso, Miriam
Astiz, Susana
Isabel, Beatriz
González Bulnes, Antonio
Correspondencia: González Bulnes, Antonio, bulnes@inia.es
Palabras clave : Antioxidants
Intrauterine-Growth-Restriction
Pregnancy
Swine-Model
Area de conocimiento FRASCATI amplio: 3. Ciencias Médicas y de la Salud
Area de conocimiento FRASCATI detallado: 3.1.6 Química Medicinal
Area de conocimiento FRASCATI específico: 3.1 Medicina Básica
Area de conocimiento UNESCO amplio: 09 - Salud y Bienestar
Area de conocimiento UNESCO detallado: 0912 - Medicina
Area de conocimiento UNESCO específico: 091 - Salud
Fecha de publicación : 2019
Volumen: volumen 20, número 5
Fuente: International Journal of Molecular Sciences
metadata.dc.identifier.doi: 10.3390/ijms20051187
Tipo: ARTÍCULO
Abstract: 
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Resumen : 
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
URI : http://dspace.ucuenca.edu.ec/handle/123456789/33316
https://www.scopus.com/record/display.uri?eid=2-s2.0-85062873820&doi=10.3390%2fijms20051187&origin=inward&txGid=341173c5c469de73a64c196cbdacfac2
URI Fuente: https://www.mdpi.com/1422-0067/20/1
ISSN : 1661-6596, 1422-0067 (e)
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
documento.pdfdocument979.19 kBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está protegido por copyright original



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Centro de Documentacion Regional "Juan Bautista Vázquez"

Biblioteca Campus Central Biblioteca Campus Salud Biblioteca Campus Yanuncay
Av. 12 de Abril y Calle Agustín Cueva, Telf: 4051000 Ext. 1311, 1312, 1313, 1314. Horario de atención: Lunes-Viernes: 07H00-21H00. Sábados: 08H00-12H00 Av. El Paraíso 3-52, detrás del Hospital Regional "Vicente Corral Moscoso", Telf: 4051000 Ext. 3144. Horario de atención: Lunes-Viernes: 07H00-19H00 Av. 12 de Octubre y Diego de Tapia, antiguo Colegio Orientalista, Telf: 4051000 Ext. 3535 2810706 Ext. 116. Horario de atención: Lunes-Viernes: 07H30-19H00