Utilidad del índice proteinuria/creatinuria comparada con Proteinuria de 24 horas para diagnóstico de preeclampsia, Hospital Vicente Corral Moscoso, 2014

Abstract

Introduction: The gold standard for detecting proteins has multiples mistakes and produces a delay in diagnosis of preeclampsia. In this study, the objective is validating the proteinuria/creatinine ratio (P/C ratio), as a faster test, available and predicting significant proteinuria in women with preeclampsia. Materials and Methods: The validity P/C ratio was determined by sensitivity, specificity, likehood ratio (LR) positive and negative. Normality test Kolmogorov-Smirnov and then logarithmic transformation base 10 by the presence of outliers. Spearman coefficient was calculated and Pearson coefficient was calculated with normally population distribution. Results: A population of 150 pregnant women was characterized by 26 years, nulliparous (67.3%), pregnancies major to 34 weeks gestation (81.3%), blood pressure average between 151/98mmHg, 71%, convulsions 3,3%, and 9.3% reported a history of preeclampsia. P/C ratio obtained sensitivity 98%, specificity 83%, LR positive of 5.85 and LR negative 0.03. In this study, population has a distribution no normally (Test Kolmogorov-Smirnov). The correlation between the P/C ratio and proteinuria of 24 hours was positive moderate (r Spearman = 0.69 [p = 0.000] and r Pearson = 0.74 [p = 0.000]). CONCLUSION: The P/C index has a moderate correlation with the gold standard and a predictive ability to discard preeclampsia. The P/C index can be used as a useful and fast alternative for the assessment of significant proteinuria in pregnant women with preeclampsia