Neuropéptidos: inflamación neurogénica en pulpa dental

Abstract

The defense mechanism of the pulpodentin complex in order protect itself from caries and dental procedures like cavity preparation, restorative procedures, among other injuries, is the inflammatory process.The pivotal role of the Nervous System in the inflammatory process of many tissues, including dental pulp, is known as neurogenic inflammation, which is mediated through neuropeptídes that are produced by the three types of nerve fibers that innervate the dental pulp: sensory, sympathetic and parasympathetic. Neurogenic inflammation is the first Iine of defense to protect tissue integrity and implies a complex Cascade of neuro-immune- vascular interactions, being a córner stone the neuroimmune interaction, on which is critical the role of neuropeptídes as immunomodulators. These neuropeptídes include Substance P (SP), Calcitonin gene-related peptide (CGRP), Neurokinin A (NKA), Vasoactive intestinal polypeptide (VIP), Neuropeptide Y (NPY), function in health and disease.