Morfina + ketorolaco vs. morfina, para el control del dolor agudo postoperatorio y disminución de los efectos secundarios del opioide, Hospital José Carrasco Arteaga. Cuenca. 2011

Abstract

Objective. Compare additional morphine requirements association with morphine + ketorolac vs morphine infusion, for the postoperative pain control during major surgery and side effects of morphine .. Methodology. With a randomized controlled trial design included two groups of 80 patients each to receive: Morf + K group: 10 mg of morphine + 30 mg of ketorolac and Morf group: 10 mg of morphine. We measured the requirements of supplemental doses of morphine and the incidence of nausea and vomiting in both groups. Results. The groups were comparable in demographic variables. In the postoperative period pain was significantly lower in group Morf + K (P <0.001). Most patients required Morf group 1 and 2 additional dose of opioid. In group Morf + K 40% did not require supplemental doses of opioid. The average dose of morphine was also lower supplementary. The differences were significant (P <0.001). 40% of patients in the ketorolac group had nausea requiring treatment with ondansetron. In group Morf all patients had nausea and fifty percent of them nausea with vomiting. Ondansetron antiemetic treatment was administered to 90% of the group. In group Morf+ K40% had nausea requiring treatment. Discussion. The association of NSAIDs to opioids is a useful scheme for effective control of postoperative pain and reduces the incidence of postoperative nausea and vomiting as side effects of morphine.