Person:
Orellana Paucar, Adriana Monserrath

Birth Date

1983-03-12

ORCID

0000-0003-1460-0990

Scopus Author ID

55159727400

Afiliación

Universidad de Cuenca, Cuenca, Ecuador
Universidad de Cuenca, Facultad de Ciencias Médicas, Cuenca, Ecuador

País

Ecuador

Organizational Units

Organizational Unit

Facultad de Ciencias Médicas

La Facultad de Ciencias Médicas de la Universidad de Cuenca fue creada en el año 1867, convirtiéndose en una de las facultades más antiguas. La Facultad de Ciencias Médicas es un lugar donde la pasión por la salud y el compromiso con el bienestar se fusionan para formar profesionales altamente capacitados en diversas disciplinas del área de la salud. Nos enorgullece ofrecer un amplio programa académico de calidad que abarca varias áreas importantes para el bienestar de nuestra comunidad. Ofrecemos un entorno de aprendizaje enriquecedor y vanguardista, con docentes altamente capacitados y recursos actualizados. Valoramos la vinculación con lo colectivo y la investigación científica, con compromiso social al igual que ética. Nuestros graduados son reconocidos por su excelencia y están preparados para afrontar los desafíos de un mundo en constante evolución.

Job Title

Profesor (T)

Last Name

Orellana Paucar

First Name

Adriana Monserrath

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Now showing 1 - 10 of 17

Child development and nutritional status in Ecuador
(2019) Huiracocha Tutivén, María de Lourdes; Orellana Paucar, Adriana Monserrath; Abril Ulloa, Sandra Victoria; Huiracocha Tutivén, Mirian Sofía; Palacios Santana, Gicela; Blume, Stuart
We assessed the development, nutritional status, and complementary feeding of 12- to 23-month-old children from Cuenca, Ecuador in 2013. Ecuador, an upper-middle-income country, developed a child policy in accordance with World Health Organization (WHO) guidelines. We collected cross-sectional survey data. Child development was assessed using the Integrated Management of Childhood Illness Guide–2011. The nutritional status was defined with WHO Child Growth Standards−2006. We investigated nutrient density, WHO Infant and Young Child Feeding Indicators, and nutrient supplementation intake of the complementary feeding. In all, 11.7% of children had “possible developmental delay,” stunting was identified in 29.4% of the children, and 25.3% faced overnutrition (overweight risk/overweight/obesity). The complementary feeding composition can be summarized as having adequate fat, high energy (MJ/day) and protein, and low iron and zinc. Children with “possible developmental delay” received less iron (P <.05) than children with normal development. Overall, 30.4% of children had minimum dietary diversity. A total of 47.7% of children received nutrient supplementation. This epidemiological profile of infants remains a challenge for Ecuador’s health programs.
Anexploratory investigation of the perspectives of educated parents on the gender roles and stereotypes in child and adolescent sexuality
(2022) Huiracocha Tutivén, María de Lourdes; Orellana Paucar, Adriana Monserrath; Abril Ulloa, Sandra Victoria; Huiracocha Tutivén, Mirian Sofía; Clavijo, María Isabel
The exploratory research presented in this article investigated the perspectives on the gender roles and stereotypes in the care of children and their sexual education of a small group of educated parents, using a patriarchal model. The sample consisted of 30 parents of which 20 participated in in-depth interviews, and 10 in two focus groups, 5 in each group. All 23 women and 7 men possessed a third-level degree, and some held apostgraduate diploma. It was found that even educated parents reproduce patterns they learned within the traditional family. A man decides and enjoys free and dominant sexuality, while a woman is required to have a beautiful body and be a wife who submits sexually to her husband. The study concludes that the caringrole of women, the subalternity and maternalism-marianism of female identity, and the care of the body and the norms of beauty are the female characteristics that still dominate social thinking. However, due to the increasing participation of women in thelabor market, women are becoming gradually more autonomous
The role of microbiota in ALS pathogenesis and progression: a literature review
(2023) Cuji Galarza, Wendy Dayanna; Cabrera Jara, Paúl Sebastián; Abril Ortiz, Pedro José; Machado Orellana, María Gabriela; Orellana Paucar, Adriana Monserrath
Introduction In recent years there has been a great interest in investigating the intestinal microbiota and its role both in healthy people and in various pathologies. This has given rise to the concept of the gut-brain axis, where the relationship between the microbiota and neurological pathologies, such as amyotrophic lateral sclerosis, whose pathogenesis is still unclear, is studied Development This review provides an overview of the role of the gut microbiota in the pathogenesis and progression of amyotrophic lateral sclerosis. Conclusions There is evidence of the role of the modulation exerted by the microbiota on the immune state as well as its direct effects on the CNS.
Programas de intervención nutricional y de actividad física en preescolares en Latinoamérica: Revisión bibliográfica
(2017) Abril Ulloa, Sandra Victoria; Morales Avilez, Diana Elizabeth; Orellana Paucar, Adriana Monserrath; Yamunaque Leon, Janneth Soraya; Palacios Santana, Gicela Monserrate; Chilet Rosell, Elisa; Huiracocha Tutivén, María de Lourdes; Monsalve, Daniela; Sempértegui León, Silvia Rocío
The material presented in this paper consists of a literature review about educative interventions promoting healthy habits in preschoolers in Latin-America. Due to changes in food patterns as a consequence of various factors such as migration, globalization, technology development, urbanization and socioeconomic status, underwent the traditional diets of this region drastic nutritional changes with an increased number of processed foods high in sugar and saturated fat. This transition coupled with a low prevalence of physical activity led to an increase in the prevalence of overweight and obesity among the different age groups including preschoolers. In fact, obesity has become a pandemic phenomenon not only in Latin American but worldwide. As a consequence, the increase in the prevalence of Chronic Non-C ommunicable Diseases (NCDs) is a health problem that requires special and urgent attention within the Health System. Therefore, educational interventions for healthy eating and physical activity are important and necessary for different age groups, especially for preschoolers since that knowledge and habits acquired at this age will probably remain during adulthood.
Turmeric oil: potential alternative for the treatment of metabolic epilepsy.
(Nova Science Publishers, 2020) Orellana Paucar, Adriana Monserrath; De Witte, Peter; Esguerra, Camila
Epilepsy is a life-shortening brain disorder that currently affects ~ 1% of the worldwide population. Despite the availability of several antiepileptic drugs (AEDs), severe side effects such as cognitive and affective disorders, teratogenicity, hepatotoxicity, among others, have been reported after chronic administration. Also, some patients remain refractory to the available AEDs. Such is the case of metabolic epilepsy. Hence, there is a current need for the discovery of novel active principles with minimal or no adverse side effects. Nature is an exciting source of potential drug candidates for the treatment of pharmacoresistant epilepsy (PRE) due to the highly diverse and complex chemical structures of bioactive vegetal compounds. In this context, we analyzed the rhizome powder of Curcuma longa, commonly known as turmeric. Until our study, the anticonvulsant properties of turmeric were exclusively attributed to its curcuminoids. For the first time, we revealed the anticonvulsant properties of turmeric oil and its main bisabolene sesquiterpenoids, ar-turmerone, α-, β-turmerone, and α-atlantone. Thus, the present chapter discusses the botanical aspects of turmeric, the chemical composition and phytopharmacological aspects of turmeric, curcumin and turmeric oil as well as our results obtained from the anticonvulsant activity characterization of turmeric oil and ar-turmerone. Our findings support further characterization of the anticonvulsant properties of these active compounds and demonstrate the usefulness of the zebrafish and mouse models for searching novel AEDs. Also, the potential therapeutic application of turmeric oil and ar- turmerone for the treatment of metabolic epilepsy is discussed.
Actividad anticonvulsiva del aceite de cúrcuma y sus constituyentes en los modelos biológicos de pez cebra y ratón
(Universitaria Abya-Yala, 2019) Orellana Paucar, Adriana Monserrath
Nutraceutical and functional properties of the andean grain amaranthus caudatus L
(Taylor & Francis, 2022) Orellana Paucar, Adriana Monserrath
A nutraceutical is a naturally occurring food compound marketed as a dietary supplement in a dosage form. This compound may possess beneficial health effects when administrated in higher quantities than those present in food. Moreover, when consumed as part of the diet in recommended amounts for daily intake, a functional food provides an adequate nutritional effect and contributes to health improvement or reduces the risk of disease (Luengo 2007). In this context, due to its characteristic protein composition with a unique qualitative and quantitative protein profile and its appealing pharmacological properties, Amaranthus caudatus is currently considered an appealing nutraceutical, functional food and drug candidate. Worldwide interest in amaranth (A. caudatus) began in the 1980s, mainly favored by a recognition endorsed by the U.S. National Academy of Sciences. Then, amaranth was included among the world’s most promising crops due to its nutritional value (National Research Council 1984)
Interactions of clinical relevance associated with concurrent administration of prescription drug and food
(2020) Orellana Paucar, Adriana Monserrath; Vintimilla Rojas, Daniela Alejandra
An inadequate combination of prescription drugs with food or medicinal plants could cause adverse effects in patients or produce negative therapeutic results. Therefore, this generic systematic review protocol aims to identify and synthesize the literature on clinical characteristics and safety issues of these types of pharmacological interactions occurring in children, adolescents, adults, pregnant/lactating women, and older adults.
Methylated flavonoids as antiseizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
(2018) Copmans, Danielle; Orellana Paucar, Adriana Monserrath; Steurs, Gert; Zhang, Yifan; Ny, Annelii; Foubert, Kenn; Exarchou, Vasiliki; Siekierska, Aleksandra; Kim, Youngju; De borggraeve, Wim; Dehaen, Wim; Pieters, Luc; De Witte, Peter AM
Epilepsy is a neurological disease that affects more than 70 million people worldwide and is characterized by the presence of spontaneous unprovoked recurrent seizures. Existing anti-seizure drugs (ASDs) have side effects and fail to control seizures in 30% of patients due to drug resistance. Hence, safer and more efficacious drugs are sorely needed. Flavonoids are polyphenolic structures naturally present in most plants and consumed daily with no adverse effects reported. These structures have shown activity in several seizure and epilepsy animal models through allosteric modulation of GABAA receptors, but also via potent anti-inflammatory action in the brain. As such, dietary flavonoids offer an interesting source for ASD and anti-epileptogenic drug (AED) discovery, but their pharmaceutical potential is often hampered by metabolic instability and low oral bioavailability. It has been argued that their drug-likeness can be improved via methylation of the free hydroxyl groups, thereby dramatically enhancing metabolic stability and membrane transport, facilitating absorption and highly increasing bioavailability. Since no scientific data is available regarding the use of methylated flavonoids in the fight against epilepsy, we studied naringenin (NRG), kaempferol (KFL), and three methylated derivatives, i.e., naringenin 7-O-methyl ether (NRG-M), naringenin 40,7-dimethyl ether (NRG-DM), and kaempferide (40-O-methyl kaempferol) (KFD) in the zebrafish pentylenetetrazole (PTZ) seizure model. We demonstrate that the methylated flavanones NRG-DM and NRG-M are highly effective against PTZ-induced seizures in larval zebrafish, whereas NRG and the flavonols KFL and KFD possess only a limited activity. Moreover, we show that NRG-DM is active in two standard acute mouse seizure models, i.e., the timed i.v. PTZ seizure model and the 6-Hz psychomotor seizure model. Based on these results, NRG-DM is proposed as a lead compound that is worth further investigation for the treatment of generalized seizures and drug-resistant focal seizures. Our data therefore highlights the potential of methylated flavonoids in the search for new and improved ASDs.
Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy
(2013) Orellana Paucar, Adriana Monserrath; Afrikanova, Tatiana; Thomas, Joice; Aibuldinov, Yelaman K.; Dehaen, Wim; De Witte, Peter A.M.; Esguerra, Camila Vicencio
In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar- turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar- turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar- turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.