Browsing by Author "Vintimilla Ugalde, Jaime Fernando"

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Antígenos HLA de clase II en pacientes con artritis reumatoide ecuatorianos y asociación con el factor reumatoide, anticuerpos anti-citrulinados y nódulos reumatoides
(2014) Vintimilla Ugalde, Jaime Fernando
Objective To determine Class II antigens in 52 patients with rheumatoid arthritis (RA) and 52 controls and establish the association of Class II antigens DRB1* with rheumatoid anti- cyclic citrullinated peptide (anti-CCP) rheumatoid factor (RF), and antibodies rheumatoid nodules. Methods and Materials Case and control study in patients from the Hospital Vicente Corral Moscoso and José Carrasco Arteaga of Cuenca-Ecuador; 52 patients with rheumatoid arthritis who satisfy the criteria of ACR-American College of Rheumatology and 52 healthy patients. The different types of HLA from each 52 patients with rheumatoid arthritis and controls were identified through PCR - Polymerase Chain Reaction. Association of HLA-DR1* with rheumatoid arthritis and rheumatoid factor, anti-citrullinated and rheumatoid nodules. The statistical analysis was done by the OR (IC 95%) and 2 of Pearson with Fisher correction and the information was processed in SPSS v15. Results The most frequency alleles were HLA-DRB1*09 (17,3%) OR 3,42 (IC95% 1,21 – 10,14) and HLADRB1* 04 (32,7%) OR 1,81 (IC95% 0,93 – 3,55). The rheumatoid factor and anti-cyclic citrullinated peptide antibodies were presented in 82,7% of patients with rheumatoid arthritis and rheumatoid nodules was detected in the 19.2% of patients with rheumatoid arthritis . An association between rheumatoid nodules with high values of rheumatoid factor and anti-ccp and these in turn with HLA-DRB1*14 y HLA-DRB1*04 alleles were found. The majority of patients with HLA-DRB1*09 alleles with heterozygote predomination had positive anti-ccp and rheumatoid factor. Conclusion The presence of HLA-DRB1*04 and HLA-DRB1*09 alleles is related with the susceptibility of present rheumatoid arthritis in Ecuadorian patients, and it is related with higher values of rheumatoid factor and anti-cyclic citrullinated peptide.
Metotrexate: Indices de mejoría y efectos colaterales, en pacientes con artritis reumatoide
(1999) Vintimilla Ugalde, Jaime Fernando; Medina Tapia, Andrés Federico; Guevara Pacheco, Sergio Vicente
The aforementioned issue, Methotrexate, improvement indices and side effects in patients with rheumatoid arthritis has been observed that the high incidence of the disease in our country, regardless of social or economic statement. Many patients come daily to see the rheumatologist in particular in institutions such as the IESS, because their ailments affecting several years and have had no improvement despite many therapies have had doctors who are not specialists and that currently very few are those with the possibilities of paying a long-term treatment, if not for life, in this thesis makes clear that the use of methotrexate in patients with rheumatoid arthritis is very useful as more than improve as significant pathological disease process allowing patients have normal life more bearable and does not cause side effects as flashy or as complicated as other medicines. Besides its low cost and simplicity of administration, and facilitate full compliance of patients throughout the study found that those who have already received MTX therapy without the drug with a certain period (1 year) and find the Clinical improvement that have the positive effects of the drug them and change your mood with regard to the disease. Now we hope that the whole process done is helpful for people suffering with incurable disease, but it is being fought timely something thanks to the knowledge and dedication of the people prepared
Osteoporosis y densidad mineral ósea baja en pacientes con artritis reumatoide, con ingesta de corticoides. Hospital Vicente Corral Moscoso. Cuenca.2018
(Universidad de Cuenca, 2020-05-21) Guevara Serrano, Karen Dayana; Guzhñay Bernal, Silvia Maribel; Vintimilla Ugalde, Jaime Fernando
Rheumatoid arthritis (RA) is a chronic inflammatory, sometimes refractory disease that may require low doses of glucocorticoids to relieve signs and symptoms, a drug that could produce a decrease in bone mass and osteoporosis with risk of fracture. OBJECTIVE: to determine the frequency of osteoporosis (OP) and low bone mineral density in patients with RA with intake of low doses of corticosteroids from Hospital Vicente Corral Moscoso. Cuenca 2018. METHODOLOGY: a retrospective descriptive, cross-sectional study in which the frequency of OP and low bone mineral density will be established in a sample of 161 patients diagnosed with RA treated with low doses of glucocorticoids (<7.5mg), who come to the external consultation of the rheumatology department in the outpatient area of the Hospital Vicente Corral Moscoso (HVCM), in the period from May 2017 to April 2018. The diagnosis of PO and decreased bone mineral density will be determined with the results of the double energy X-ray absorptiometry (DEXA, for its acronym in English). The statistical analysis will be through basal tables in addition to graphs and the Chi square test that allows to compare the observed distribution of the data. RESULTS: the study will establish the frequency of OP and low bone mineral density in patients with RA who take low doses of corticosteroids that go to the rheumatology department in the outpatient area of the Hospital Vicente Corral Moscoso in the period between May 2017 to April 2018.
Prevalence of musculoskeletal disorders and rheumatic diseases in Cuenca, Ecuador: a WHO-ILAR COPCORD study
(2016) Guevara Pacheco, Sergio Vicente; Feican Alvarado, Elsa Astrid; Sanín, Luz Helena; Vintimilla Ugalde, Jaime Fernando; Vintimilla Moscoso, Oscar Fernando; Delgado Pauta, Jorge Antonio; Lliguisaca Segarra, Maria Angelita; Dutan Erraez, Holger Gonzalo; Guevara Mosquera, Sergio Daniel; Ochoa Robles, Maria Veronica; Cardiel, Mario H; Pelaez Ballestas, Ingris
The aim of this study was to determine the prevalence of musculoskeletal pain and rheumatic diseases in subjects over 18 years of age from the canton of Cuenca, Ecuador. Cross-sectional analytical community-based study was conducted in subjects over 18 years of age using the validated Community-Oriented Program for the Control of Rheumatic Diseases (COPCORD) questionnaire. Random sampling was used. The questionnaire was administered by standardized health workers. Subjects were visited house by house. Subjects positive for musculoskeletal (MSK) pain in the last 7 days and at some point in life were assessed by rheumatologists to confirm the diagnosis. A total of 4877 subjects participated, with an average age of 42.8 (SD 18.8) years of age; 59.7 % were women; 69.7 % lived in urban areas. 32.5 % reported MSK pain in the last 7 days and 45.7 % at some point in life. The prevalence of knee osteoarthritis was 7.4 %, hand osteoarthritis 5.3 %, low back pain 9.3 %, rheumatoid arthritis 0.8 %, fibromyalgia 2 %, gout 0.4 %, and lupus 0.06 %. Subjects from rural areas reported experiencing more MSK pain in the last 7 days and at some point in life, lower income, poorer health-care coverage, and increased physical activity involving repetitive tasks such as lifting weights or cooking with firewood. MSK pain prevalence was high. Osteoarthritis and low back pain were the most common diseases. Age, sex, physical activity, repetitive tasks, living in a rural area, and lack of health-care coverage were found to be associated with MSK pain. © 2016, Springer-Verlag Berlin Heidelberg.
Validación del cuestionario COPCORD para detección de enfermedades reumáticas CUENCA - ECUADOR
(2014) Pelaez Ballestas, Ingris
Objective: To validate the cultural adaptation of the instrument (Community Orientate Pro-gram in the Rheumatic Diseases) COPCORD to detect musculoskeletal pain and rheumatic diseases in the population of Cuenca.Methodology: A COPCORD transcultural ques-tionnaire validation and its application were made in the community to identify rheumatic symptoms. A rheumatologist doctor checked people to define the diagnosis. A descriptive statistical analysis of each variable was per-formed. Chronbach alpha, analysis screening test (sensitivity, specificity, and positive predic-tive value and roc curves) was measured.Results: A total of 201 people participated, 106 in urban areas and 95 in rural areas. The 67.6% were women with an average age of 50.3 years with 7.5 years in school. The 57.7% reported musculoskeletal pain with an inten-sity of 5.8 for VSA. Comparing the COPCORD questionnaire with the clinical assessment of the rheumatologist an 83.72% of sensitivity, was observed, specificity of 61.14%, probability of 2.18 and area under the curve of 0.72; with a Cronbach’s alpha of 0.7 for pain characteris-tics and 0,9 for functional capacity.Conclusion: The COPCORD questionnaire is valid for using in rural and urban populations in Ecuador; it demonstrated good performance as a screening test.