Browsing by Author "Ugalde Puyol, Jorge Edmundo"

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Expresión tisular de proteínas reparadoras del sistema microsatelital y su distribucion de acuerdo a factores pronósticos en cáncer colorrectal en SOLCA-Cuenca 2004-2014
(2017) Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Martínez Reyes, Fray Cleiton
Globally, colorectal cancer is the third most common neoplasm in men and the second in women. Its occurrence is related to factors dependent on the patient and molecular alterations. The identification of the pathways of tumorogenesis, allows us to subclassify patients and protocolize treatments. Microsatellite instability is one such path; Is present in 15% to 20% in colorectal carcinoma and its presence is associated with a better prognosis. Objective: To determine the frequency of tissue expression of reparative proteins of the microsatellite system and their distribution according to prognostic factors in biopsies of patients with colorectal cancer attended at the Solca-Cuenca Cancer Institute during the period 2004-2014. Method: It is a cross-sectional, analytical study. Results: We studied 240 patients with colorectal cancer. 37.9% were men and 62.1% were women. The mean age was 66.2 years. The 58.75% (n = 141) had colon location. A lack of protein expression was observed in 24.2% (58 patients). As for proteins, 68.96% (40 cases) were MLH1 / PMS2; 1.72% (1 case) MSH2 / MSH6. Of the cases that did not express the proteins, 87.93% were located in the colon; 79.3% were adenocarcinoma; 58.6% were moderate grade and 37.9% were stage II. In the bivariate analysis, a statistically significant association was established between microsatellite instability with tumor localization (OR 7.4, CI 3.2-17) and degree of differentiation (OR 2.8, CI 1.5-5.4)
Sobre-expresión de la proteína p 16 en biopsias con diagnóstico de NIC I, positivas para Genoma de Papiloma Virus Humano. Instituto del Cáncer. SOLCA Cuenca-Ecuador. 2009-2010.
(Universidad de Cuenca. Facultad de Ciencias Médicas, 2015-12) Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Palta González, Araceli Miroslava; Picón Coronel, María Gabriela
Numerous studies report that overexpression of p16 protein that is a biomarker to identify premalignant exocervical epithelium lesions would have a high association with human papillomavirus (HPV) with high oncogenic risk. It is a descriptive correlational study whose objective was to establish association of Cervical Intraepithelial Neoplasia grade I (CIN I), HPV positive, with the p16 expression. Materials, methods and results: It is a correlational study conducted from November 2009 to November 2010; about 256 cases of CIN I were presented, 72 were positive HPV; also p16 technique was performed. The women average age was 41 years. There were 40 (55.6%) positive cases for p16, and only 32 (44.4%) were negative. From the positive cases for p16, the most common viral types were high-risk patients: 33 (82.5%). The p16 was valued in amount, distribution and intensity, establishing a relationship between the intensity of p16 with high-risk virus (p = 0.038). When the age and viral type were analyzed, patients between 20 and 40 years (36 cases, 90%) presented HPV genome with high risk. Conclusions: There is correlation between the intensity of p16 with the presence of HPV high risk, helping select groups prone to disease progression.