Browsing by Author "Thapa, Kriti"

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    The effect of albendazole treatment on non-seizure outcomes in patients with symptomatic neurocysticercosis
    (2018) Thapa, Kriti; Romo, Mathew; Carpio Rodas, Luis Arturo; Denise, Leslie; Andrews, Howard; Hauser, Wallen; Kelvin, Elizabeth A
    Background Randomized controlled trials have found an inconsistent effect of anthelmintic treatment on long-term seizure outcomes in neurocysticercosis. The objective of this study was to further explore the effect of albendazole treatment on long-term seizure outcomes and to determine if there is evidence for a differential effect by seizure type. Methods In this trial, 178 patients with active or transitional neurocysticercosis cysts and new-onset symptoms were randomized to 8 days of treatment with albendazole (n= 88) or placebo (n= 90), both with prednisone, and followed for 24 months. We used negative binomial regression and logistic regression models to determine the effect of albendazole on the number of seizures and probability of recurrent or new-onset seizures, respectively, over follow-up. Results Treatment with albendazole was associated with a reduction in the …