Browsing by Author "Quizhpe Andrade, Diana Elizabeth"

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    Estudio farmacodinámico de losartán en pacientes hipertensos atendidos en el consultorio médico del GAD Municipal de Gualaceo
    (2017) Quizhpe Andrade, Diana Elizabeth; Zhingri Villavicencio, Ruth Noemí; Zaruma Torres, Fausto Leonardo; Soto Seminario, Salma Katiuska
    The objective of the present study was get a population pharmacodynamic model of losartan in hypertensive patients treated in the office of the Municipal Autonomous Decentralized Government (GAD) of Gualaceo, by means of mixed effects models, associating them with the covariables of each patient. Fifty hypertensive patients of both sexes, from 41 to 90 years of age and who met the established inclusion and exclusion criteria, were evaluated. The values of systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse were obtened; before and after the administration of losartan in a random manner, within a range of 1, 2, 3 and 6 hours post-dose. In addition, all relevant information was collected, such as his medical history and anthropometric measurements. The population pharmacodynamic parameters (PopPD) were determined through 60 different modeling and simulation evaluations using Monolix- 2016R1; by which the dose / response relationship was established for SBP, DBP and pulse) It was determined that the best structural model PopPD was referred to as Mlxt: immed. Emax _null, constant (-2 log likelihood = 447.20 for the systolic pressure, 449.81 for the diastolic pressure and 448.46 for the pulse). The parameters that were obtained were the average effective concentration (EC50) and the maximum effect (Emax). The evaluation of the model with covariates determined that age, schooling, cholesterol, triglycerides influence SBP; height, weight, body mass index (BMI), diabetes modify on the PAD and; the size, triglycerides affect the pulse. The aforementioned covariates influenced the determination of the EC50 whose value was set at 115, 110 and 130 mg/L for SBP, DBP and pulse respectively; but it did not present a significant impact on the Emax parameter.