Browsing by Author "Quezada Chonillo, Bryan Ronny"

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    Uso de Malva sylvestris y Malva pseudolavatera en el desarrollo de cápsulas nutracéuticas
    (Universidad de Cuenca, 2025-06-03) Quezada Chonillo, Bryan Ronny; Sarmiento Tomalá, Glenda Marcela
    The use of medicinal plants in the development of nutraceuticals plays a primary role due to the high composition of phytochemicals with great health benefits. In this sense, Malva sylvestris and Malva pseudolavatera constitute a potential resource for these purposes. For this reason, the objective of the work was to develop hard capsules with fine nutraceuticals from the hydroalcoholic extracts of both species. The main quality control parameters of the plant material and hydroalcoholic extracts were determined through the analysis of their physical- chemical indices. Phenols, flavonoids, carbohydrates, proteins and alkaloids were quantified in the extracts, and analysis was performed by ultraviolet and infrared spectroscopy. Hard capsules were developed from granules obtained from hydroalcoholic extracts, by the wet granulation method, which met the quality specifications referred to in the pharmacopoeias. The designed formulations are evaluated for physical-chemical parameters (organoleptic properties, average weight, filling mass and disintegration time), chemical indices (using spectrophotometric and spectroscopic techniques) and microbiological control for 12 months, achieving good stability under the conditions of established packaging and storage. The hydroalcoholic extracts and formulations of the two species show antioxidant activity. Likewise, the inhibitory effect of xanthine oxidase was demonstrated. The results justify the feasibility of the employment of the extracts of M. sylvestris and M. pseudolavatera in the development of hard capsules with fine nutraceuticals for their antioxidant activity and inhibitory qualities of xanthine oxidase, useful in degenerative diseases, all of which contributes to scientific support for these plants with wide use in Ecuador.