Browsing by Author "Puruncajas Espinoza, Marco Antonio"

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    Evaluación de la eficacia de un antipsicótico atípico combinado con un inhibidor de la recaptación de la serotonina en pacientes con Enfermedades Funcionales Gastrointestinales por medio del Cuestionario GSRS, en el GASTROCENTER-González, en el periodo enero 2018 a diciembre 2023
    (Universidad de Cuenca. Facultad de Ciencias Médicas, 2026-01-21) Puruncajas Espinoza, Marco Antonio; Pizarro Marín, Juan Diego; González Domínguez, Esteban Horacio
    Functional gastrointestinal disorders (FGIDs) are chronic conditions that significantly affect quality of life and propose a therapeutic challenge because conventional treatments have limited efficacy. This study aimed to evaluate the efficacy of combining an atypical antipsychotic with a selective serotonin reuptake inhibitor (SSRI) in patients with FGIDs, using the GSRS scale as a clinical assessment tool. An observational, retrospective, longitudinal study was conducted at GASTROCENTER-González (Cuenca, Ecuador), including 134 patients treated between 2018 and 2023. Treatment resulted in a significant improvement in gastrointestinal symptoms, with the total GSRS score decreasing from 61.79 ± 11.54 to 37.10 ± 11.18 (p < 0.001), and a shift toward lower severity categories. Quetiapine monotherapy and its combination with SSRIs showed comparable efficacy, with no statistically significant differences between regimens. Therapeutic response was not associated with sociodemographic variables or symptom duration. In conclusion, pharmacological neuromodulation with quetiapine, alone or combined with SSRIs, represents an effective and well-tolerated therapeutic option that significantly improves gastrointestinal symptoms and quality of life, providing clinical evidence to optimize the comprehensive management of FGIDs.