Browsing by Author "Parkhouse, Robert Michael"

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    Comparison of complementary diagnostic tests in cerebrospinal fluid and serum for neurocysticercosis
    (2018) Romo, Matthew L.; Carpio Rodas, Luis Arturo; Parkhouse, Robert Michael; Cortéz, María Milagros; Rodríguez Hidalgo, Richar
    The role of immunologic tests in the diagnosis of neurocysticercosis (NC) is controversial and few studies have made comparisons among them. The objective of this study was to compare immunological tests in both serum and cerebrospinal fluid (CSF) for the diagnosis of NC. We conducted a case-control study in Cuenca, Ecuador, enrolling patients with NC (N = 24) and matching them with other neurosurgical patients (N = 18). To detect cysticercal antigen, we used an HP10 antigen assay in serum and CSF (“HP10 Ag -serum -CSF”) and a commercial antigen assay in serum (apDia, “ELISA-Ag-serum”), and to detect cysticercal DNA, we used a polymerase chain reaction (PCR) assay in CSF (“PCR-CSF”). Assay sensitivities were HP10 Ag-serum (41.7%, 95% confidence interval [CI] 22.1–63.4), HP10 Ag-CSF (87.5%, 95% CI: 67.6–97.3), ELISA-Ag-serum (62.5%, 95% CI: 40.6–81.2), and PCR-CSF (79.2%, 95 …