Browsing by Author "Orellana Paucar, Adriana Monserrath"

Now showing 1 - 20 of 35

Aceptación y actitudes hacia las vacunas contra COVID-19 en cuidadores de niños entre las edades 5 - 12 años en la ciudad de Cuenca, durante el año 2022
(Universidad de Cuenca, 2024-01-04) Blandín Lituma, Paula Eliana; Orellana Paucar, Adriana Monserrath
Background: Sars-CoV-2 is the causal agent of COVID-19, a virus that caused the global pandemic with 765 million confirmed cases and 6.9 million deaths (Ndwandwe & Wiysonge, 2021). The need to understand the factors that are present in society and that caused vaccine hesitancy became a challenge during the pandemic, therefore; Several investigations have been dedicated to studying the opinions of caregivers regarding the COVID-19 vaccine for their children. Objectives: Determine the level of acceptance and attitudes towards COVID-19 vaccines by caregivers of children between the ages of 5 - 12 years in the city of Cuenca and its associated factors. Methods: Cross-sectional analytical study with convenience sampling applied to caregivers of children aged 5 to 12 in the city of Cuenca (n=458). Results: The population surveyed is 458 participants, where an acceptance of 87,9% was obtained by the caregivers of children from 5 to 12 years old, variables such as gender and ease of vaccination; They were aspects that contributed to the acceptance of vaccines. Conclusions: Perceptions of the short protection period of the vaccines, the unreliable supply of vaccines that Ecuador was going to have contributed to the rejection; This is not the case with the ease of being able to vaccinate children, especially mothers whose predisposition to vaccinating their children is greater.
Actividad anticonvulsiva del aceite de cúrcuma y sus constituyentes en los modelos biológicos de pez cebra y ratón
(Universitaria Abya-Yala, 2019) Orellana Paucar, Adriana Monserrath
Andean traditional medicine plants. The case of “Limpia” (Cleansing ceremony)
(Taylor & Francis, 2022) Orellana Paucar, Adriana Monserrath
The Andean worldview embraces a holistic understanding of well-being. For Andean Traditional Medicine (ATM), health comprises the internal energetic equilibrium of the individual and the equivalent energetic balance with the surrounding environment. The human being should be in harmony with the family, the community, Nature and the Cosmos to achieve complete welfare (Mathez-Stiefel et al. 2007).Rupture of this energetic balance causes disease. Therefore, treatment focuses on restoring the original stability in the body and the soul (Bautista-Valarezo et al. 2020). For this purpose, plants are the primary therapeutic resources described in ATM (Houghton 1995). The World Health Organization (WHO) promotes the rational use of complementary therapy—including herbal remedies—to ensure widespread therapeutical coverage, especially in developing countries. The application of herbal medicines as co-adjuvant of prescribed drugs could support the administration of minimum effective doses to lessen the probability of dose-dependent adverse reactions. They may contribute to improving adherence to the prescribed pharmacological therapy
Anexploratory investigation of the perspectives of educated parents on the gender roles and stereotypes in child and adolescent sexuality
(2022) Huiracocha Tutivén, María de Lourdes; Orellana Paucar, Adriana Monserrath; Abril Ulloa, Sandra Victoria; Huiracocha Tutivén, Mirian Sofía; Clavijo, María Isabel
The exploratory research presented in this article investigated the perspectives on the gender roles and stereotypes in the care of children and their sexual education of a small group of educated parents, using a patriarchal model. The sample consisted of 30 parents of which 20 participated in in-depth interviews, and 10 in two focus groups, 5 in each group. All 23 women and 7 men possessed a third-level degree, and some held apostgraduate diploma. It was found that even educated parents reproduce patterns they learned within the traditional family. A man decides and enjoys free and dominant sexuality, while a woman is required to have a beautiful body and be a wife who submits sexually to her husband. The study concludes that the caringrole of women, the subalternity and maternalism-marianism of female identity, and the care of the body and the norms of beauty are the female characteristics that still dominate social thinking. However, due to the increasing participation of women in thelabor market, women are becoming gradually more autonomous
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.
(2012) Orellana Paucar, Adriana Monserrath; Serruys, Ann Sophie K.; Afrikanova, Tatiana; Maes, Jan; De Borggraeve, Wim; Alen, Jo; León Tamariz, Fabián; Wilches Arizabala, Isabel Maria; De Witte, Peter A.M.; Esguerra, Camila V.
urmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further, we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity.
Calificación de productores y proveedores de materia prima (leche cruda) de lácteos San Antonio C.A:
(2007) Orellana Paucar, Adriana Monserrath; Bermeo Aguirre, Cristian Javier; Astudillo Machuca, Adelina
Child development and nutritional status in Ecuador
(2019) Huiracocha Tutivén, María de Lourdes; Orellana Paucar, Adriana Monserrath; Abril Ulloa, Sandra Victoria; Huiracocha Tutivén, Mirian Sofía; Palacios Santana, Gicela; Blume, Stuart
We assessed the development, nutritional status, and complementary feeding of 12- to 23-month-old children from Cuenca, Ecuador in 2013. Ecuador, an upper-middle-income country, developed a child policy in accordance with World Health Organization (WHO) guidelines. We collected cross-sectional survey data. Child development was assessed using the Integrated Management of Childhood Illness Guide–2011. The nutritional status was defined with WHO Child Growth Standards−2006. We investigated nutrient density, WHO Infant and Young Child Feeding Indicators, and nutrient supplementation intake of the complementary feeding. In all, 11.7% of children had “possible developmental delay,” stunting was identified in 29.4% of the children, and 25.3% faced overnutrition (overweight risk/overweight/obesity). The complementary feeding composition can be summarized as having adequate fat, high energy (MJ/day) and protein, and low iron and zinc. Children with “possible developmental delay” received less iron (P <.05) than children with normal development. Overall, 30.4% of children had minimum dietary diversity. A total of 47.7% of children received nutrient supplementation. This epidemiological profile of infants remains a challenge for Ecuador’s health programs.
Comportamiento alimentario y actividad física en niños de 3-4 años del municipio.
(2018) Espinoza Coello, Pamela Monserrath; Velásquez Ortíz, María del Carmen; Abril Ulloa, Sandra Victoria; Orellana Paucar, Adriana Monserrath
Background: The preschool stage is the starting point in the creation of habits that will be present in the future, so we must observe the places where the behavior of children develops. General Aim: Observe the eating behavior and physical activity in 3-4 year old children of the Municipal Child Development Centers of the city of Cuenca (CDIs). Methodology: A mixed study was carried out, the qualitative inductive part was developed through non-participatory observations to preschoolers and their educators, analyzing their eating behavior and physical activity. 9 interviews were carried out with the kitchen staff of the CDIs to explore the practices that influence the eating behavior and quality of the menu. The descriptive quantitative study was carried out using a validated dietary quality questionnaire. Results: It was observed that children at the table behave according to the interaction of educators who use strategies to consume the preparations. It was observed that preschoolers do not comply with the recommendation of physical activity and have a prolonged sleep time after lunch. In the interviews, it was found that each CDI carries their organization, and they modify the menu according to several reasons, some of which provide benefits and other disadvantages. The quality of the menus according to the COMES questionnaire was acceptable to improvable. Conclutions: Preschoolers consume three meal times in the CDIs. For this reason, it is necessary to pay attention to the factors that influence the eating behavior and physical activity.
Determinación de la frecuencia de infección por helicobacter pylori y parasitosis en preescolares de 2 a 4 años que acuden a los centros de desarrollo infantil del municipio de la ciudad de Cuenca. Julio, 2015
(Universidad de Cuenca, 2016-11-11) Maldonado Guanga, Gladys Teresa; Buestán Buestán, Doris Elizabeth; Orellana Paucar, Adriana Monserrath; Abril Ulloa, Sandra Victoria
This study was aimed to determine the frequency of Helicobacter pylori and intestinal parasitosis in children from 2 to 4 years attending to daycare centers of Cuenca´s City Hall. Stool samples were collected at daycare centers with colaboration of parents and caretakers. Sample analysis were carried out according to quality control and biosafety standards at the Laboratory of Diagnostic Center of the Faculty of Medical Sciences of the University of Cuenca. Fresh examination was employed for identification of intestinal parasites and immunochromatographic technique for qualitative determination of Helicobacter pylori. Results of this study evidenced a prevalence of 26,1% for Helicobacter pylori infection and 219,3% for intestinal parasitosis in these daycare centers. Entamoeba histolytica was identified as the etiologic agent in 58,8% of parasitosis cases
Evaluación del nivel de conocimiento sobre interacciones alimento - medicamento en profesionales de la salud de Azuay-Ecuador, 2022
(Universidad de Cuenca, 2023-05-03) Rodriguez Arce, Roberto Antonio; Orellana Paucar, Adriana Monserrath
Background: Food-drug interactions consist of the kinetic or dynamic alteration of a drug caused by a nutritional component, presenting synergism, decrease or inhibition of drug absorption, distribution, metabolism and excretion. Recent advances on pharmacological and nutritional interactions indicate the need to prevent them to improve pharmacological treatment. However, they are little known by health professionals, so training and updating at an academic and hospital level is required to provide better patient care. Objective: To determine the level of knowledge about food-drug interactions in health professionals from Azuay-Ecuador, 2022. Method: Cross-sectional analytical design. Through the application of a validated survey on food-drug interactions, the level of knowledge on this subject was evaluated in 330 doctors and 110 biochemists/chemists-pharmacists, selected by convenience sampling. The data was analyzed, tabulated and presented in descriptive tables with percentages and frequencies. Statistical significance was determined using the chi square test. Fisher´s test was used to determine if there is a relationship between the study factor and the variables. Results: 55.80% of doctors and 60.00% of biochemists/pharmaceutical chemists presented a low level of knowledge about food-drug interactions. Conclusions: The mean knowledge score in the group of biochemists/pharmaceutical chemists surveyed was 13/30 (43.33%) and in doctors it was 14/30 (46.66%), corresponding to a low level of knowledge. The findings of this study indicate that there is no clear correlation between the level of knowledge about food-drug interaction and the age, gender, profession, years of experience and level of education of the participants.
Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy
(2013) Orellana Paucar, Adriana Monserrath; Afrikanova, Tatiana; Thomas, Joice; Aibuldinov, Yelaman K.; Dehaen, Wim; De Witte, Peter A.M.; Esguerra, Camila Vicencio
In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar- turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar- turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar- turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.
Interacciones medicamento – nutriente y medicamento – planta medicinal en el tratamiento farmacológico de la diabetes con insulina: revisión sistemática cualitativa
(Universidad de Cuenca, 2020-07-27) García Moscoso, Claudia Nataly; Tigre Sinchi, María Eugenia; Orellana Paucar, Adriana Monserrath
Background: According to the World Health Organization (WHO), 422 million adults have diabetes; consequently, the WHO is promoting the adoption of preventive and therapeutic measures, as well as the control of complications (1). The interactions of drugs with food and medicinal plants not only interfere with the use of nutrients and the effect of the drugs; they can additionally alter the nutritional status of the patient (2) Objective: to synthesize the scientific evidence on the clinically relevant aspects of drug-nutrient and drug medicinal plant interactions in the pharmacological treatment of diabetes with insulin. Methodology: A qualitative systematic review of articles of primary origin was developed on the reported interactions between insulin with nutrients and/or with medicinal plants. Results: Executing the search equations designed for this study, 1,009 articles were found, of which two were selected, using the inclusion criteria. In the first, the absence of drug-medicinal plant interaction was reported, while in the second, the drug-nutrient interaction of the pharmacokinetic type at the absorption level was reported. Conclusions: The present qualitative systematic review reports the absence of interaction between insulin and guar gum, and also reports the pharmacokinetic interaction between insulin and nutrients in a standard diet. This knowledge will guide the correct combination and administration of the medication in order to achieve optimal therapeutic results.
Interacciones medicamento – nutriente y medicamento – planta medicinal en el tratamiento farmacológico de la epilepsia: revisión sistemática
(2019-03-13) Mosquera López, Erick Thomás; Bustamante Alvarez, Nancy Michelle; Orellana Paucar, Adriana Monserrath
Background. Inadequate combination of prescription drugs with nutrients or plants can generate adverse effects or unexpected therapeutic results. The systematic review on this subject will favor the access to compiled information, of a scientific nature, on the possible interactions derived from the joint administration of drugs with nutrients or plants. Aim. Synthesize the scientific evidence on the clinically relevant aspects of drugnutrient and drug-plant interactions in the pharmacological treatment of epilepsy. Methodology. A qualitative systematic review of articles of primary origin on the interaction between phenytoin and nutrients or plants. Results. 816 articles were obtained by applying search equations for this study and 14 of them were selected according to the established criteria. In five of them, the absence of interactions were reported; in three, improvement in drug absorption; in one, increased toxicity; in three, synergism interactions were identified and, in two, inhibition of the anticonvulsant effect. Conclusions. The joint administration of macronutrients with phenytoin does not generate pharmacological interactions in some cases, although there are exceptions in which synergism, inhibition of pharmacological effect or improved absorption occurs. With reference to micronutrients, pyridoxine and folic acid produce synergism. In addition, supplemented folic acid and piperine, a constituent of black pepper, improve the anticonvulsant absorption while the joint administration of phenytoin with the commercial product "Noni Juice" (Morinda citrifolia L.), generates inhibition of the anticonvulsant effect. On the other hand, Rhodiola rosea produces increased toxicity of phenytoin.
Interacciones medicamento–nutriente y medicamento–planta medicinal en el tratamiento farmacológico de la epilepsia con ácido valproico: revisión sistemática cualitativa
(Universidad de Cuenca, 2020-08-28) Cabrera Benavides, Fabiola Marisol; Herrera Agudelo, Jessica; Orellana Paucar, Adriana Monserrath
BACKGROUND. The importance of studying drug-medicinal plant interactions lies at the critical point of being able to identify and prevent adverse effects in the future and at the same time modulate potential beneficial interactions.(1) In the United States, the Poison Control Center has reported nearly 200,000 hospital admissions due to the adverse drugs events. Psychiatric - drugs such as antidepressants, selective serotonin receptor inhibitors are responsible for 30.3% of cases, atypical antipsychotics 24.1% and other types of antidepressants 21.5% of them. (2) In this country, it has been reported that 20% of the population consumes herbal medicines with other medicines simultaneously and 70% of them do not report this information during consultation with their treating physician.(1) GENERAL AIM. To synthesize the scientific evidence about the clinically relevant aspects of drug-nutrient and drug-medicinal plant interactions in the pharmacological treatment of epilepsy with valproic acid. METODOLOGY. Qualitative systematic review that analyzed articles of primary origin about reported interactions between valproic acid with nutrient / food or with medicinal plants. RESULTS. By applying the search equation and the search criteria, 909 articles were obtained, 12 studies were discarded, and the remaining 10 articles met the inclusion criteria. Of these, seven articles reported nutrient-drug interactions of pharmacokinetic type and one of them corresponds to medicinal plant-drug interaction. On the other hand, one reported a pharmacodynamics nutrient-drug interaction due to exacerbation of side effects related to liver dysfunction, and 2 articles reported absence of interaction.
Interactions of clinical relevance associated with concurrent administration of prescription drug and food
(2020) Orellana Paucar, Adriana Monserrath; Vintimilla Rojas, Daniela Alejandra
An inadequate combination of prescription drugs with food or medicinal plants could cause adverse effects in patients or produce negative therapeutic results. Therefore, this generic systematic review protocol aims to identify and synthesize the literature on clinical characteristics and safety issues of these types of pharmacological interactions occurring in children, adolescents, adults, pregnant/lactating women, and older adults.
Las relaciones de convivencia de los niños, niñas y adolescentes sordos o hipoacústicos: estudio cualitativo exploratorio
(2015) Huiracocha Tutivén, María de Lourdes; Blume, Stuart; Orellana Paucar, Adriana Monserrath; Brito Roby, Liliana Alexandra; Abril Ulloa, Sandra Victoria; Chilet Rosell, Elisa; Diaz Granda, Ruth Cumanda; Sempértegui León, Silvia Rocío; Palacios Santana, Gicela Monserrate; Monsalve Neira, Maria Daniela; Barahona Huiracocha, Jorge Alfonso; Artega H., Sebastián; Almeida Pozo, Juan Carlos; Huiracocha Tutivén, Mirian Sofía
Medicina tradicional andina
(Universidad de Cuenca, 2020) Brito Roby, Liliana Alexandra; Achig Balarezo, David Ricardo; Angulo Rosero, Aydee Narcisa; Huiracocha Tutivén, María de Lourdes; Orellana Paucar, Adriana Monserrath; Mosquera Vallejo, Lorena Elizabeth; Barrera Luna, Geovanny Patricio
Methylated flavonoids as antiseizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
(2018) Copmans, Danielle; Orellana Paucar, Adriana Monserrath; Steurs, Gert; Zhang, Yifan; Ny, Annelii; Foubert, Kenn; Exarchou, Vasiliki; Siekierska, Aleksandra; Kim, Youngju; De borggraeve, Wim; Dehaen, Wim; Pieters, Luc; De Witte, Peter AM
Epilepsy is a neurological disease that affects more than 70 million people worldwide and is characterized by the presence of spontaneous unprovoked recurrent seizures. Existing anti-seizure drugs (ASDs) have side effects and fail to control seizures in 30% of patients due to drug resistance. Hence, safer and more efficacious drugs are sorely needed. Flavonoids are polyphenolic structures naturally present in most plants and consumed daily with no adverse effects reported. These structures have shown activity in several seizure and epilepsy animal models through allosteric modulation of GABAA receptors, but also via potent anti-inflammatory action in the brain. As such, dietary flavonoids offer an interesting source for ASD and anti-epileptogenic drug (AED) discovery, but their pharmaceutical potential is often hampered by metabolic instability and low oral bioavailability. It has been argued that their drug-likeness can be improved via methylation of the free hydroxyl groups, thereby dramatically enhancing metabolic stability and membrane transport, facilitating absorption and highly increasing bioavailability. Since no scientific data is available regarding the use of methylated flavonoids in the fight against epilepsy, we studied naringenin (NRG), kaempferol (KFL), and three methylated derivatives, i.e., naringenin 7-O-methyl ether (NRG-M), naringenin 40,7-dimethyl ether (NRG-DM), and kaempferide (40-O-methyl kaempferol) (KFD) in the zebrafish pentylenetetrazole (PTZ) seizure model. We demonstrate that the methylated flavanones NRG-DM and NRG-M are highly effective against PTZ-induced seizures in larval zebrafish, whereas NRG and the flavonols KFL and KFD possess only a limited activity. Moreover, we show that NRG-DM is active in two standard acute mouse seizure models, i.e., the timed i.v. PTZ seizure model and the 6-Hz psychomotor seizure model. Based on these results, NRG-DM is proposed as a lead compound that is worth further investigation for the treatment of generalized seizures and drug-resistant focal seizures. Our data therefore highlights the potential of methylated flavonoids in the search for new and improved ASDs.
Nivel de conocimiento sobre interacciones alimento-medicamento y factores asociados en la población del cantón Cuenca, 2023
(Universidad de Cuenca, 2024-03-25) Jácome Arias, Johana Paulina; Orellana Paucar, Adriana Monserrath
Background: Food-drug interactions affect drug pharmacokinetics, drug release, absorption, distribution, metabolism or elimination in the human body. Objectives: To determine the level of knowledge about food-drug interactions and associated factors in the population of Cuenca, Ecuador 2022-2023. Method: Validated 12-question questionnaire. Cross-sectional analytical study. Participants: 442. Sample size: was calculated with the EPIDAD 4.2 program. Data analysis: Stata MP-64.exe was used. Inferential analysis: the chi-square test was used, considering a difference of p value < 0.05 as significant. Type of association: the ODSS ratio was calculated with its confidence interval, considering as a risk factor values greater than 1, protective factor results less than 1, indifferent if equal to 1. Results: The 43.67%, of the surveyed population, respond affirmatively about having knowledge about the interaction between foods. The 51.13% recognize that over-the-counter medications and medications prescribed by the physician do not interact with herbal remedies and supplements. The 73.08% state that they have been recommended to avoid alcohol intake with medications. The 84.4% personnel related to the health area have knowledge about these interactions. Conclusions: It is evident in questions E, I the participants present a low level of knowledge of 14.03% and4.98% respectively. Moderate knowledge in A 43.67%, B 51.13%, D 40.27%, F 47.29%, G 36.20%, H 52.71%, J 34.16%, K 31.67% and L 36.20%. In question D there is a high level of knowledge of 73.08%.
Nutraceutical and functional properties of the andean grain amaranthus caudatus L
(Taylor & Francis, 2022) Orellana Paucar, Adriana Monserrath
A nutraceutical is a naturally occurring food compound marketed as a dietary supplement in a dosage form. This compound may possess beneficial health effects when administrated in higher quantities than those present in food. Moreover, when consumed as part of the diet in recommended amounts for daily intake, a functional food provides an adequate nutritional effect and contributes to health improvement or reduces the risk of disease (Luengo 2007). In this context, due to its characteristic protein composition with a unique qualitative and quantitative protein profile and its appealing pharmacological properties, Amaranthus caudatus is currently considered an appealing nutraceutical, functional food and drug candidate. Worldwide interest in amaranth (A. caudatus) began in the 1980s, mainly favored by a recognition endorsed by the U.S. National Academy of Sciences. Then, amaranth was included among the world’s most promising crops due to its nutritional value (National Research Council 1984)