Browsing by Author "Lema Morocho, Alexandra Abelina"

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Prevalencia y factores de riesgo de la colecistitis aguda en el Hospital Homero Castanier en el año 2014
(2015) Montes Fernández, Bety Belén; Lema Morocho, Alexandra Abelina; Ordóñez Cumbe, Julio César; García Alvear, Jorge Luis
BACKGROUND: Acute cholecystitis is one of the main disorders of the bile duct in the country and is strongly associated with cholelithiasis. From 90 to 95% of cases of acute cholecystitis are caused by gallstones, which in 2013 was the second cause of national morbidity. Morbidity in the province of Cañar is also significant, showing a value of 36.98 per 10,000 population (1).GENERAL OBJECTIVE: Determine the prevalence of acute cholecystitis and associated risk factors in Homero Castanier Crespo Hospital during 2014.METHODOLOGY: A descriptive, retrospective cross-sectional study, where we worked with the universe of patients in whose medical records existed diagnosis of acute cholecystitis, and were treated at the Homero Castanier Crespo Hospital during 2014. Data were collected in form (questionnaire) and were tabulated in SPSS (version 21). For statistical analysis of the data, were handled: percentages, simple frequencies and averages; for association was used Chi squared with its confidence interval 95%. The results are considered statistically significant at p <0.05.RESULTS: The prevalence of acute cholecystitis was 24.9% of the total cholecystectomy patients in Homero Castanier Crespo Hospital. Acute cholecystitis represented an 88.33%. The age group in which more frequently presented the pathology was adult (45%) and females (66.7%) and the population of the urban area (76.7%). Dyslipidemic patients are 70.0% of cases of acute cholecystitis. Statistically significant association between BMI and diagnosis of acute cholecystitis/acalculous with p of 0.040 was found. No statistically significant association with other risk factors analyzed was found. CONCLUSIONS: There is statistically significant association between BMI and diagnosis of acute cholecystitis / acalculous
Triple-negative breast cancer in Peru: 2000 patients and 15 years of experience
(2020) Ku, Gabriel De la Cruz; Luyo Avalo, Shirle Marianne; Morante Cruz, Zaida Denisse; Moller, Mecker G.; Chambergo Michilot, Diego; Enríquez Vera, Daniel Jair; Flores, Lucero; Luque Benavides, Renato Gustavo; Saavedra Ubillus, Sonia Antonella; Eyzaguirre Sandoval, Miguel Eduardo; Lujan Peche, María Guadalupe; Noel Pajuelo, Naysha Milushka; Calderon, Hafid; Razuri, César; Fuentes, Hugo Alejandro; Cotrina, José Manuel; Neciosup, Silvia P.; Araujo, Jhajaira; Lema Morocho, Alexandra Abelina; Pinto, Joseph; Gomez, Henry Leonidas; Valcárcel, Bryan
Background Epidemiological studies commonly identify the clinical characteristics and survival outcomes of patients with breast cancer at five years. Our study aims to describe the sociodemographic, clinicopathological characteristics and determine the long-term event-free survival (EFS) and overall survival (OS) of a Peruvian population with triple-negative breast cancer. Methods We reviewed the medical records of new cases treated at a single institution in the period 2000–2014. The survival analysis included patients with stages I-IV. Survival estimates at 10 years were calculated with the Kaplan-Meier method and compared with the Log-rank test. We further used multivariate Cox regression analysis to calculate prognostic factors of recurrence and mortality. Results Among the 2007 patients included, the median age at diagnosis was 49 years (19–95 years). Most patients presented histologic grade III (68.7%), tumor stage II (34.2%), and III (51.0%) at diagnosis. Local and distant relapse was present in 31.9 and 51.4% of the patients, respectively. The most frequent sites of metastasis were the lungs (14.5%), followed by bone (9.7%), brain (9.6%), and liver (7.9%). The median follow-up was 153 months. At 3, 5, and 10 years, the EFS of the population was 55%, 49%, and 41%, respectively, while the OS was 64%, 56%, and 47%, respectively. Moreover, an N3 lymph node status was the most important prognostic factor for both disease relapse (HR: 2.54, 95% CI: 2.05–3.15) and mortality (HR: 2.51, 95% CI: 2.01–3.14) at ten years. An older age and higher T staging were associated with a worse OS, while patients who received radiotherapy and adjuvant chemotherapy had better survival rates. Conclusion The sociodemographic features of Peruvian patients with TNBC are similar to those of other populations. However, our population was diagnosed at more advanced clinical stages, and thus, EFS and OS were lower than international reports while prognostic factors were similar to previous studies.