Browsing by Author "Goercke Torres, Sonia Amayra"

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Actividad antiinflamatoria e inmunoestimulante de dos especies del género Uncaria - revisión bibliográfica
(Universidad de Cuenca, 2022-05-18) Chaca Maxi, Carolin Viviana; Naranjo Miranda, José Estuardo; Cazar Ramírez, María Elena; Goercke Torres, Sonia Amayra
Introduction: Our organism triggers an inflammatory process as an initial and nonspecific response to physical, chemical or microbiological stimuli, in order to remedy and limit the injury or damage caused. The immune system acts as a defense mechanism against pathogens, generating a variety of cells and molecules specialized in recognizing and eliminating the harmful agent, so it is important to investigate the effects of Uncaria tomentosa and Uncaria guianensis in antiinflammatory and immunostimulant treatments. Main Objective: To analyze current information, from 2015 to 2021, on compounds and metabolites with antiinflammatory and immunostimulant activity of two species of Uncaria genus. Methodology: Bibliographic review of documentary type; a total of 24 articles and publications were included; corresponding to the period between 2015 to 2021, the information search was carried out in databases such as ScienceDirect (ELSEVIER ®), PubMed, Scielo and through the Google Scholar search engine, information from previous years to those mentioned, non-original articles whose information and veracity is not clear were excluded. Results: Information was obtained about the extracts and compounds of U. tomentosa and U. guianensis, where metabolites such as alkaloids, anthocyanidins, flavonoids, sterols, tannins, etc., were reported, the anti-inflammatory and immunostimulant activity is attributed to the pentacyclic and tetracyclic oxindole alkaloids due to their action on the nervous and immune systems, with mitraphylline being the major alkaloid and the flavanol Kaempferitrin produced only in U. guianensis. The synergy of the metabolites in the two species has allowed obtaining a better therapeutic response, so it is recommended not to isolate them. In addition, extracts of U. tomentosa and U. guianensis with antiinflammatory and immunostimulant activity have been reported, mainly hydroalcoholic, ethanolic and alcoholic extracts. Conclusion: Due to the increase of inflammatory and immunological disorders worldwide, especially in underdeveloped countries, this research proposes U. tomentosa and U. guianensis species as an important source of anti-inflammatory and immunostimulant compounds, of which oxindole alkaloids are considered responsible for these therapeutic actions. Therefore, it is recommended to study the development of new medicinal formulas based on plants that achieve the desired therapeutic objective, in addition to having less cytotoxicity with respect to more complex drugs and that are supportive in the treatment of various conditions of interest
El género Phaedranassa (Amaryllidaceae) como fuente promisoria de metabolitos bioactivos ante la enfermedad de Alzheimer - Revisión Bibliográfica
(Universidad de Cuenca, 2022-07-22) Inga Criollo, Marcelo Esteban; Maldonado Mejía, Lenin Ismael; Cazar Ramírez, María Elena; Goercke Torres, Sonia Amayra
Amaryllidaceae family comprises a group of plant genders distributed worldwide, developing in tropical and subtropical habitats., 33 species of plants from this family grow in Ecuador, of which 12 are endemic. The genus Phaedranassa belongs to this family, being distributed in Ecuador, Colombia and Costa Rica. Phaedranassa cuencana was reported for the first time in 2015, in Sevilla de Oro (Azuay, Ecuador). Its common names are “cebolla de cerro”, “urco cebolla” or “amancay”, highlighting its beautiful flowers. Phaedranassa dubia is a bulbous terrestrial shrub, with common names of “papa del lobo” o “cebolla de gallinazo”. This specie is native to the Ecuador and Colombia Andes, in Ecuador this plant is distributed in Carchi, Imbabura, Napo and Pichincha provinces. Phaedranassa tunguraguae is an endemic species of Ecuador, it is found in the central-eastern Ecuadorian Andes from Tungurahua province. Members of the Amaryllidaceae family produces promising secondary metabolites. Currently, the isolation of 300 alkaloids, classified in nine groups are reported. In the genus Phaedranassa, bioactive alkaloids such as galantamine, phenadramine, hemantamine, pseudolicorin have been identified. These molecules are therapeutic agents for Alzheimer disease (AD) treatment. The aim of this work was to analyze scientific literature referring to the bioactivity of secondary metabolites from Phaedranassa dubia, Phaedranassa cuencana y Phaedranassa tunguraguae, as therapeutic agents against Alzheimer's disease. Information retrieved from 2015 to 2021 in the databases: Scielo, ScienceDirect, PubMed y Redalyc was analyzed. This work contributed to raise awareness regarding new treatments for neurodegenerative diseases, which affects vulnerable population. The literature review identified Phaedranassa cuencana as a promising source of galantamine, the alkaloid used as main treatment for Alzheimer disease.
Extractos orgánicos de Chenopodium ambrosioides (paico), Artemisia absinthium (ajenjo), Ocimum basilicum (albahaca) y Peperomia inaequiafolia (congona) como agentes antiamebianos
(2018-11-11) Quillay Cuji, José Eugenio; Goercke Torres, Sonia Amayra; Cazar Ramírez, María Elena
In the present project, the potential of organic extracts of Chenopodium ambrosioides (paico), Artemisia absinthium (ajenjo), Ocimumbasilicum (albahaca), Peperomia inaequalifolia (congona), were assessed as a source of secondary metabolites anti-amoebic was evaluated. The aim was to standardize a bioassay to evaluate the anti-amoebic activity "in vitro" of substrates of natural origin, comparing its bioactivity with the effect of reference drugs. The experimental work was performed at the Parasitology Laboratory of the Faculty of Chemical Sciences of the University of Cuenca. The target parasite, Entamoeba histolytica, was isolated from human stool samples and maintained in Diamond medium. The evaluation of the test was performed by staining with 0.01% Eosin, and then counting the live and dead parasites. Amoeba maintenance and viability were monitored for 24, 48 and 72 hours. The surviving parasites were subjected to various concentrations of plant extracts in order to assess the anti-amoebic efficacy. The results obtained allowed develop a technique to evaluate natural products with anti-amoebic potential and to identify potential plant species with active anti-amoebic to be included in future studies.