Browsing by Author "Fleury, Agnes"

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    Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35–55 in cerebral spinal fluid
    (2020) Parkhouse, Michael; Sciutto, Edda; Hernández, Marisela; Cortez, Maria; Carpio Rodas, Luis Arturo; Fleury, Agnes
    Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considerably reduced or absent in the P-NC samples. There was a striking correlation between levels of anti-tubulin and anti-MOG, and the significant correlation between the levels of autoantibodies and cellularity in the CSF, suggests that stimulation of the autoantibody response may be a function of cerebral inflammation. A hypothetical model to describe the pathogenesis of EP-NC is presented
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    Guideline on treatment of neurocysticercosis: some observations
    (2013) Buerno De las casas, Jorge G; Carpio Rodas, Luis Arturo; Vega Gama, Jose Gustavo; Rueda Franco, Fernando; Sethi, Nitin K; Wiebe, Sam; Halperin, John J; Escalaya, Alejandro L; Fleury, Agnes; Garcia Pedroza, Felipe; González Duarte, Alejandra; Baird, Ruth Ann; Zunt, Joseph R; Roos, Karen L
    Baird et al.[1] demonstrated that there are few evidence-based studies of antihelminthic treatment for neurocysticercosis (NC). This guideline has some limitations. The authors' procedure was to evaluate treatment based on the reduction of number of cysts. This method is misleading because if only one cyst out of many remains alive after treatment, it could prompt continued or recurrence of symptomsThe only valid criterion should be the disappearance of all viable parasites.[2] The authors' recommendation of albendazole treatment to reduce seizure frequency is questionable. The authors studied results that included patients with vesicular (live parasite) infections and patients with colloidal (degenerative/dead parasite) infections to evaluate treatment effect on seizures. It may be inaccurate to combine those studies because--considering the role of inflammation in …
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    Neurocysticercosis in Latin America: Current epidemiological situation based on official statistics from four countries
    (2022) Romo, Matthew L.
    he present work shows the current trends in the frequency of neurocysticercosis hospitalizations in four endemic Latin American countries. Neurocysticercosis is a parasitic disease of the central nervous system that has been historically linked to poverty and poor sanitation. It is one of the neglected tropical diseases included in the PAHO/WHO action plan for their elimination. We compiled official data available from Brazil, Colombia, Ecuador, and Mexico. Our results show a clear and significant reduction in the disease burden in 3 of the 4 countries included. On the other hand, in Colombia, an increase in incidence was observed. These mixed results are of great relevance. They allow us to be optimistic about the possibility of eliminating this disease in some countries, but also allow us to consider why the disease does not seem to be controlled in other countries and direct public health measures aimed at eliminating this parasite in the countries that need it most.