Browsing by Author "Fesel, Constantin"

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    Anti-brain protein autoantibodies are detectable in extraparenchymal but not parenchymal neurocysticercosis
    (2020) Parkhouse , Robert Michael Evans; Carpio Rodas, Luis Arturo; Cortéz, María Milagros; Von Kriegsheim, Alex; Fesel, Constantin
    Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy. © 2020 Elsevier B.V.