Browsing by Author "Espinoza Calle, Glenda Iralda"

Filter results by typing the first few letters
Now showing 1 - 5 of 5
  • Thumbnail Image
    Item
    Detección de la mutación JAK2 V617F en neoplasias mieloproliferativas en población ecuatoriana por reacción en cadena de la polimerasa alelo específica
    (2017) Campoverde Cisneros, Manuel Alfredo; Oliveros Alvear, Jorge William; Reyes Peña, Ines Maria; Maldonado Guerrero, Bella Irma; Becerra Navarrete, Edgar Antonio; Ullauri Zambrano, Veronica Alexandra; Villa Cardenas, Esteban Homero; Espinoza Calle, Glenda Iralda; Ladines Castro, Washington Javier; Chacon Velez, Jennifer Yadira; Arcentales Cayamcela, Mauro Javier
    In 2005, five independent research groups reported the association of V617F mutation in the gene encoding the janus kinase 2 (JAK2) Myeloproliferative Neoplasms Small (NMP), including polycythemia vera (PV), Essential thrombocytosis (ET) and primary myelofibrosis (MFP). This study aimed to detect the JAK2 V617F mutation in Ecuadorian patients through chain reaction polymerase allele specific (AS-PCR). The research design was descriptive cross-sectional and included a total of 40 patients, 20 with NMP and 20 controls attending the various services Haematology Health Institutions participating. Genetic material was extracted and then amplified by AS-PCR, while the clinical hematology of NMP was performed by using specialized clinical, morphological and hematological tests such as blood counts and flow cytometry examination hematologists. The frequency of the JAK2 V617F mutation found was 50% with a rate of 95% confidence. Patients with a greater presence of the mutation (35%) were those with PV, followed by patients with TE (15%), the average age being 45. These data confirm that the JAK2 V617F mutation is prevalent in NMP and has become the molecular marker of both the PV, ET and MFP. Likewise, this study has shown that the AS-PCR method is a quick, easy and cost-effective diagnosis.
  • Thumbnail Image
    Item
    Factores poblacionales y operativos intervinientes en la determinación de sintomáticos respiratorios: programa de control de tuberculosis provincia del Azuay área no. 6 2004
    (2006) Espinoza Calle, Glenda Iralda; Vásquez Santander, Jessika Araceli; Villavicencio Naula, Piedad Fabiola; Andino Vélez, José Gerardo
  • Thumbnail Image
    Item
    Prevalencia y factores asociados a respuesta completa a la primera línea de quimioterapia en pacientes con diagnóstico de linfoma difuso de células b, en el Instituto del Cáncer Solca Cuenca-Ecuador
    (Universidad de Cuenca, 2023-04-03) Maldonado Cabrera, Byron René; Espinoza Calle, Glenda Iralda
    Lymphomas are a heterogeneous group of lymphoproliferative disorders that are classified according to their histology, of which B-cell lymphomas represent 80% of all lymphomas. Diffuse large B-cell lymphoma (DLCGB) is the most frequent form of lymphoma, representing 30-35% of the total. Several cytotoxic therapies have been developed, which seek a better therapeutic response with the lowest degree of adverse events, the first-line chemotherapy is RCHOP with an adequate response. The factors associated with the response to first-line treatment are stage, age, general condition, LDH levels, tumor burden.
  • Thumbnail Image
    Item
    Pruebas biométricas básicas en la práctica odontológica. Valores alterados
    (Universidad de Cuenca, 2016) Lafebre Carrasco, Milton Fabricio; Reinoso Carrasco, Julieta Del Carmen; Espinoza Calle, Glenda Iralda; Serrano Delgado, Clara Yamile
    The current challenge to the dentist in oral health care is to treat patients with complex medical problems that may have diseases such as diabetes mellitus, hypertension, heart diseases or pa- tients who take drugs that alter blood clotting. The aim oí this literatura review is to provide basic tools forthe interpretation of the valúes reported in the laboratory tests that are used in dentistry; which correspond to figurative elements that are found in blood (white blood cells, red blood cells and platelets), the coagulation factors and their possible alterations in patients with blood dys- crasias; for which a systematic review has been carried out (scoping review), using biliographic databases Pubmed, Scopus and Virtual Health Library. Detailed information has been taken re- garding the normal valúes of the tests mentioned, however in the literatura it has been reported that most of the patients are subjected to unnecessary preoperative studies that increase costs and morbidity of the procedure, therefore it is important to consider that normal valúes of any la- boratory test are included in two standard deviations. Therefore 2,5 % of healthy individuáis will have a borderline valué and 2,5 % will have a supranormal valué.
  • Thumbnail Image
    Publication
    Tratamiento de pacientes con afectación grave por COVID-19, con plasma de pacientes convalecientes de COVID-19
    (Universidad del Azuay, 2020) Espinoza Calle, Glenda Iralda; Paredes Sanchez, Johanna Elizabeth; Aguirre Bermeo, Hernan Marcelo; Martinez Carvallo, Luis Alberto; Peña Patiño, Sandra Gioconda; Lopez Aguirre, Wilson Javier; Holguin Carvajal, Juan Pablo; Cobos Villavicencio, Paul Ramiro; Ortega Berrezueta, Jaime Fernando; Hernandez Quito, Elvia Lucrecia; Dita Salabert, Liermis Michael; Duque Proaño, Galo Ruben