Browsing by Author "Czarnowski, Daniel"

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    Integrin α6 (CD49f), the microenvironment and cancer stem cells
    (2019) Czarnowski, Daniel; Gerard J., Madlambayan; Tyler, Parsons; Bigoni Ordóñez, Gabriele Davide; Luis G., Villa Diaz
    Cancer is a highly prevalent and potentially terminal disease that affects millions of indi- viduals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumori- genic characteristics and collect evidence demonstrating the importance of integrin 6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC popula- tions in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnect- ing them with the tumorigenic microenvironment.