Browsing by Author "Cruz Barrera, Juan Oscar"

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    Biomarcadores y dianas moleculares para uso terapéutico en el cáncer de tiroides. Una revisión sistemática según las directrices PRISMA
    (Universidad de Cuenca, 2025-04-28) Orbe Suárez, Elian Fabricio; Cruz Barrera, Juan Oscar; Jaramillo Oyervide, Julio Alfredo
    Background: A biomarker represents a biological molecule that predicts a clinically relevant outcome or an intermediate indicator that is more complicated to observe directly and may or may not be involved in pathological processes (11). These markers can be applied in the detection, diagnosis, understanding, treatment and monitoring of diseases (26). Objective: To synthesize scientific evidence data on biomarkers and molecular targets in papillary thyroid cancer. Methods: Retrospective observational study of systematic review of the literature. It was carried out using Preferred Reporting Items for Systematic Reviews and Meta- Analysis (PRISMA). Five international electronic databases were used. The collection instrument was a data extraction matrix in Microsoft® Excel® 2019. Criteria used to determine eligible articles and evidence classification systems such as Sackett and GRADE for quality assessment. Finally, a descriptive statistical analysis and a narrative synthesis. Results: Thirteen articles were analyzed. In the clinical context of patients with papillary thyroid cancer, we found the expression of cells such as CD8, PD-L1, ANGPTL4, NAG-1 or expression of several genes and miRNAs associated with prognostic and diagnostic capacity of the disease. Moreover, compounds such as Quercetin and its relationship with PD-L1/NAG/pro-NAG-1, Ginsenoside RH2 with the regulation of miR-524-5p or Neferin with NRF2 involving the Nrf2/HO-1/NQO1 pathway showed promising therapeutic potential for the treatment of papillary thyroid cancer. Conclusions: Some drugs, such as ginsenoside Rh2, neferin and quercetin, have shown promising antitumor effects in PTC.