Browsing by Author "Cabrera Orellana, Boris Gustavo"

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    Valor diagnóstico de las enzimas gamma glutamil transpeptidasa y fosfatasa alcalina frente a la ecografía en la detección de coledocolitiasis en el Hospital Vicente Corral Moscoso- Cuenca, enero - junio 2016
    (2016) Cabrera Orellana, Boris Gustavo; Caguana Calle, Jennifer Paola; Cantos Ormaza, Juan Edison
    Background: elevation of gamma glutamyl transpeptidase and alkaline phosphatase enzymes have been used for diagnosis of choledocholithiasis. There are studies that evaluate its elevation to detect choledocholithiasis have shown inconclusive results. General Objective: determine the diagnostic value of gamma glutamyl transpeptidase enzymes and alkaline phosphatase versus ultrasound in detecting choledocholithiasis in patients with symptoms of obstructive jaundice syndrome at the Vicente Corral Moscoso hospital. Methodology: descriptive study of a diagnostic test 108 medical records of choledocholithiasis were found. Sensitivity, specificity, predictive values were measured: positive, negative likelihood values; positive, negative gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (FA), was compared to standard ultrasound test considered to be the test performed on the reference health center gold. Results. GGT: sensitivity 96.30% (92.27 - 100), specificity 98.98% (97.86 - 100); PPV and NPV of 96.30% (92.27 - 100) 98.98% (97.86 - 100) respectively, the ratio of positive and negative 94.37 (35.57 - 250.36) likelihood, 0.04 (0.01 to 0.1) respectively. FA: sensitivity 93.52% (88.41 - 98.62), specificity 99.74% (99.12 - 100); PPV and NPV of 99.02% (96.62 - 100) 98.24% (96.82 - 99.66) respectively, positive likelihood ratio 366.59 (51.74 - 2597.6), negative likelihood ratio 0.06 (0.03 to 0.13). The combination of both enzymes against ultrasound has sensitivity, specificity: 91.67% (85.99 - 97.34), 99.49% (98.66 - 100) respectively, VPP 98.02% (94.81 - 100). Conclusion: the increased GGT and FA are valid tests for the diagnosis of choledocholithiasis