Browsing by Author "Buestan Zambrano, Juan Fernando"

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A systematic review on modulation of oral biofilm and immune response associated to mucosa with probiotic bacteria as a potential approach in the prevention of dental caries
(BP Internacional, 2021) Rodríguez Coyago, María de Lourdes; Buestan Zambrano, Juan Fernando; Yamunaque Vire, Jessica Micaela; Pinos Gavilanes, Maria Paz; Osorio Ayala, Lesly Damaris
Background: A variety of approaches have been developed for the control of dental caries, a pathology with high incidence and prevalence worldwide. The use of probiotic strains for the modulation of dental biofilm in the prevention of caries has been studied, but the available evidence shows varied methodologies; and the strains tested differ from one study to another. Objective: To analyze the efficacy of using probiotic strains to prevent caries through the modulation of biofilm and immune response associated to oral mucosa. Methods: A search was made in the scientific bases PubMed, Cochrane and Science Direct, prioritizing randomized double and triple-blind clinical trials from 2010 to 2020, including a total of 20 studies to be analyzed. The selection criteria were consistent with the Preferred Reporting Items for Systematic Reviews protocol. Results: Within the studies, different types of probiotic bacteria were analyzed, dominating Lactobacillus paracasei. While most clinical trials show a favorable response in terms of a significant reduction of Streptococcus mutans in the oral microbiota, very few studies evaluated salivary pH and sIgA levels. Conclusions: The heterogeneity of the studies analyzed and the multifactorial nature of dental caries do not allow us to ensure that probiotic therapy is completely effective in preventing this pathology. Although probiotic therapy can help by regulating the microbiological factor, there are other determinants that can favor the development of caries and that are barely approached in their relationship with bacteriotherapy. Future studies that homogeneously evaluate the use of probiotics could give us a clearer idea of their effectiveness
Clinicopathological and molecular markers in metastasizing ameloblastoma: a systematic review of case reports
(2021) Buestan Zambrano, Juan Fernando
Ameloblastoma is a benign odontogenic tumour that is aggressive and localised in nature, listed as the first or second most prevalent odontogenic tumour and rarely tends to metastasis, but when it does, it receives the definition adopted by the WHO in 2017 of metastasizing ameloblastoma. Materials and Methods This systematic review of clinical case reports of metastasizing ameloblastoma from the last 10 years, collected from PubMed, Science Direct and Cochrane digital databases, aims to search for association between clinical/pathological and/or molecular parameters of ameloblastoma and its metastatic potential. Results The targeted search yielded 14 publications with a total of 18 clinical cases, which showed a mean age for diagnosis of metastasizing ameloblastoma of 46 years, with no gender predilection and a high probability of occurrence in the yellow Asian race, favouring a pattern of distant dissemination. The highest frequency of metastasis was associated with mandibular primary lesions diagnosed in young patients, and, the most frequently found variant was the multicystic solid type, follicular subtype; distant metastasis was the predominant form of presentation, with the lungs being the main target. Conclusions At the moment , there is nothing that can predict metastatic potential in ameloblastoma. More standardised studies exploring the molecular terrain are needed, as this is a key and understudied factor.
Eficacia de la bacterioterapia probiótica para la prevención de caries dental: una revisión sistemática de la literatura
(2020) Osorio Ayala, Lesly Damaris
Background: A variety of approaches have been developed for the control of dental caries, a pathology with high incidence and prevalence worldwide. The use of probiotic strains for the modulation of dental biofilm in the prevention of caries has been studied, but the available evidence shows varied methodologies; and the strains tested differ from one study to another. Objective: To analyze through a systematic review of clinical trials, the efficacy of using probiotic strains to prevent dental caries. Methods: A search was made in the scientific bases PubMed, Cochrane and Science Direct, prioritizing randomized double and triple-blind clinical trials from 2010 to 2020, including a total of 20 studies to be analyzed. The selection criteria were consistent with the Preferred Reporting Items for Systematic Reviews protocol. Results: Within the studies, different types of probiotic bacteria were analyzed, dominating Lactobacillus Paracasei. While most clinical trials show a favorable response in terms of a significant reduction of Streptococcus mutans in the oral microbiota, very few studies evaluated salivary pH and sIgA levels. Conclusions: The heterogeneity of the studies analyzed and the multifactorial nature of dental caries do not allow us to ensure that probiotic therapy is completely effective in preventing this pathology. Although probiotic therapy can help by regulating the microbiological factor, there are other determinants that can favor the development of caries and that are barely approached in their relationship with bacteriotherapy. Future studies that homogeneously evaluate the use of probiotics could give us a clearer idea of their effectiveness.
Metastasizing ameloblastoma: a systematic review in search of clinicopathological predictors
(2021) Buestan Zambrano, Juan Fernando; RODRIGUEZ COYAGO, MARIA LOURDES
Introduction: Ameloblastoma is a benign odontogenic tumor that is aggressive and localised in nature, listed as the first or second most prevalent odontogenic tumor and rarely tends to metastasis, but when it does, it receives the definition adopted by the WHO in 2017 of metastasizing ameloblastoma. Materials and Methods: This systematic review of clinical case reports of metastasizing ameloblastoma from the last 10 years, collected from PubMed, ScienceDirect and Cochrane digital databases, aims to search for association between clinical/pathological and/or molecular parameters of ameloblastoma and its metastatic potential. Results: The targeted search yielded 14 publications with a total of 18 clinical cases, which showed a mean age for diagnosis of metastasizing ameloblastoma of 46 years, with no gender predilection and a high probability of occurrence in the yellow Asian race, favouring a pattern of distant dissemination. The highest frequency of metastasis was associated with mandibular primary lesions diagnosed in young patients, and the most frequently found variant was the multicystic solid type, follicular subtype; distant metastasis was the predominant form of presentation, with the lungs being the main target. Conclusion: At the moment, there is nothing that can predict metastatic potential in ameloblastoma. More standardised studies exploring the molecular terrain are needed, as this is a key and understudied factor
Modulation of oral biofilm and immune response associated to mucosa with probiotic bacteria as a potential approach in the prevention of dental caries: a systematic review
(2020) Osorio Ayala, Lesly Damaris; Buestan Zambrano, Juan Fernando; Yamunaque Vire, Jessica Micaela; Pinos Gavilanes, Maria Paz; Rodriguez Coyago, Maria De lourdes
Background: A variety of approaches have been developed for the control of dental caries, a pathology with high incidence and prevalence worldwide. The use of probiotic strains for the modulation of dental biofilm in the prevention of caries has been studied, but the available evidence shows varied methodologies; and the strains tested differ from one study to another. Objective: To analyse through a systematic review of clinical trials, the efficacy of using probiotic strains to prevent dental caries. Methods: A search was made in the scientific bases PubMed, Cochrane and Science Direct, prioritizing randomized double and triple-blind clinical trials from 2010 to 2020, including a total of 20 studies to be analysed. The selection criteria were consistent with the Preferred Reporting Items for Systematic Reviews protocol. Results: Within the studies, different types of probiotic bacteria were analysed, dominating Lactobacillus Paracasei. While most clinical trials show a favorable response in terms of a significant reduction of Streptococcus mutans in the oral microbiota, very few studies evaluated salivary pH and sIgA levels. Conclusion: The heterogeneity of the studies analysed and the multifactorial nature of dental caries do not allow us to ensure that probiotic therapy is completely effective in preventing this pathology. Although probiotic therapy can help by regulating the microbiological factor, there are other determinants that can favor the development of caries and that are barely approached in their relationship with bacteriotherapy. Future studies that homogeneously evaluate the use of probiotics could give us a clearer idea of their effectiveness.
Síndrome de la apnea obstructiva del sueño: Revisión de la literatura
(2020) Buestan Zambrano, Juan Fernando; Abad Ortiz, Hugo Alejandro; Barzallo Sardi, Vinicio Egidio; Arias Murillo, Yanela Lisbeth; Yunga Picon, Maria Yolanda
Obstructive sleep apnea syndrome or OSAS is a sleep disorder of multifactorial etiology, which consists of partial or total obstruction of the upper airways, which could be critical in severe cases, it can occur in children and adults, some of its Clinical manifestations and symptoms include craniofacial anomalies, sleep quality deterioration, drowsiness, headaches, alterations in cognitive performance which have a great negative impact on the quality of life of people who suffer from it, it can also be associated with other pathologies or syndromes. According to studies, its prevalence is significant for it to be present in the daily appointment. The objective of this study was to carry out a review of the literature on OSAS from a dental perspective that helps us to better understand this pathology that allows us to collaborate in an early detection of it. 23 scientific articles from 2005 to 2020 were collected from the PubMed database that provide us with evidence about its pathogenesis, diagnostic methods, prevalence, severity, and treatment. According to the literature, the gold standard for diagnosis is polysomnography and there is no unanimous management protocol, especially in non-surgical therapy, that is why studies suggest that the management should be multidisciplinary orthodontist-doctor for its optimization. The importance of further studies on its treatment is highlighted.