Volúmen 34 No . 3 (2016)

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Browsing Volúmen 34 No . 3 (2016) by Author "Calle Saquipay, Ángel Domingo"

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    Neurodesarrollo en el hipotiroidismo congénito y sus particularidades electroencefalográficas
    (Universidad de Cuenca. Facultad de Ciencias Médicas, 2016-12) Calle Ulloa, Boris Eduardo; Calle Saquipay, Ángel Domingo; Hurtado Matute, Johanna Alexandra; Cobos Castro, Johanna Elizabeth; Pinos Brito, María Carmen
    Congenital hypothyroidism (CH) is a result of a deficiency of thyroid hormone (TH) by altering thyroid (primary hypothyroidism), or pituitary causes (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism). Thyroid hormone at the tissue level, is involved in the maturation and functional differentiation of various organs such as the development of the central nervous system (CNS), in which an insufficient supply of HT in time and place, resulting in permanent abnormalities, history highlighting the irreversible intellectual deficit. In the world’s population it has been estimated a frequency of 1: 300 to 1: 4000 newborns. The treatment is oral supplementation with thyroxin. OBJECTIVE: To describe the neurodevelopmental congenital hypothyroidism and electroencephalographic characteristics. MATERIALS AND METHOD: It is an observational, descriptive and cross-sectional study in preschool children diagnosed with HC, who were administered the Denver II scale, a comprehensive neurological evaluation and a digital electroencephalogram. RESULTS: A total of 12 patients, 7 (58%) female and 5 (42%) males were evaluated. All patients were evaluated by the scale of Denver II, 4 (33%) were delayed in their psychomotor development, predominantly in the language area. Regarding the neuro-pediatric assessment was found that 5 patients had neurological manifestations and perform digital electroencephalogram 7 (59%) had electroencephalographic changes, 5 (71%) showed immaturity and 2 (29%) dysfunction. CONCLUSIONS: Afer the analysis made throughout this investigation, the conclusions are: The results of this study show a heterogeneous pattern, however target the possible association between clinical manifestations and electroencephalographic findings. Patients with congenital hypothyroidism present a condition in the area of language which was determined by applying the scale Denver II. The abnormal clinical manifestations are mainly in the verbal area, but they are also presented as subtle manifestations or unspecific as inattention, irritability and behavioral disorders. Keywords: Congenital Hypothyroidism, Neurodevelopmental Disorders, Neurologic Manifestations, electroencephalography