Síndrome de boca ardiente idiopático, construcción de un modelo etiopatogénico de la población femenina

Abstract

Introduction: burning mouth syndrome is defined as a type of chronic orofacial pain of unknown etiology, although several publications describe it as a neurological disorder with multifactorial pathogenesis. Objective: to propose an etiopathogenic model of burning mouth syndrome, based on clinical and preclinical evidence published to date. Material and methods: bibliographic research and review of the literature through a systematic search of articles published in English in the last 20 years in four scien- tific databases. Results: it’s proposed to consider burning mouth syndrome as an oral neuropathy, influenced by low-grade systemic inflammation caused by intestinal dysbiosis or psychiatric disor- ders; and exacerbated in peri- or post-menopausal women given their deficiency in neuroprotective steroids and their greater propensity for psycholog- ical disturbances. It’s recommended to characterize taxonomical and functionally the gut microbiome of psychiatric diseases women with and without stomatopyrosis. Conclusions: it’s necessary to develop lines of research that seek to taxonomically and functionally characterize the intestinal microbiome of psychiatric conditions women, with and without BMS, to elucidate the pathogenesis of BMS and find new therapeutic targets that allow better management of the syndrome with more stable responses.