Frecuencia de positividad de marcadores tumorales CA-125 y CEA en pacientes con cáncer de ovario del Hospital de Especialidades Médicas José Carrasco Arteaga periodo 2019

Abstract

Ovarian epithelial cancer is the fifth cause of mortality in Europe, with an incidence of 6-14 cases per 100,000. 90% of ovarian tumors develops in epithelial cells, and postmenopausal women are the most prone to suffer from it; the average age of individuals diagnosed with this disease is 54 years. Survival from ovarian cancer in 2010-2014 was estimated between 30% and 50% at a 5-year rate worldwide; in Ecuador it reached 37,9% at 5-year rate, and in Quito, in 2013-2015, it was 46%. The purpose of this descriptive study was to determine the frequency of positivity rate of tumor markers Ca-125 and CEA patients with ovarian cancer at José Carrasco Arteaga Hospital, 2019. Data was collected through a questionnaire and analyzed by simple and cross tabulation, using percentages and frequencies. Statistical data was tabulated using IBM SPSS Statistics trial version and Microsoft Excel software programs. Results showed that the most frequent age range of patients with ovarian cancer in 2019 was 51-60 years (32.5%); 59,6% had a family history of cancer, and 73,9% were postmenopausal. The frequency of positivity rate of tumor marker CA-125 was 49,8% (101) and CEA was 15,3% (31). Significant alteration of CA-125 was found in the late stage of the disease (26,1%); significant alteration of CEA was found in the late stage of the disease (8,9%). CA-125/CEA ratio >25 identified 89,7% of epithelial ovarian cancer, while 10,3% was excluded (<25).