Dental pulp fibroblast: a star cell
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Date
2022-09-19
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad de Cuenca
Abstract
Introduction
Dental pulp fibroblasts (DPF) are the most abundant cell type in the dental pulp.
They play pivotal roles; however, they are often mistaken to be involved only in the
repair and maintenance of this connective tissue.
Methods
We used the search terms “pulp fibroblast,” “complement system proteins,” “pulp
inflammation,” “angiogenesis,” and “dentin pulp regeneration” to identify articles from
the PubMed and Scopus databases
Results
These sentinel cells produce all complement system proteins participating in defense
processes, control of inflammation, and dentin-pulp regeneration; produce several
proinflammatory cytokines and chemokines and express patternrecognition
receptors, demonstrating their involvement in immunoregulatory mechanisms;
express neuropeptides and their receptors, playing an important role in neurogenic
inflammation and dental pulp wound healing; secrete angiogenic growth factors as
well as neurotrophic proteins, essential for dentin-pulp regeneration; regulate
neuronal plasticity processes; and can sense the external environment.
Conclusion
This review highlights that DPFs are more than mere passive cells in pulp biology
and presents an integrative analysis of their roles and functions.
Resumen
Keywords
Odontología, Endodoncia, Pulpa dental, Fibroblastos, Endodoncia regenerativa
Citation
Código de tesis
Código de tesis
ODONEN;020