Caracterización de escherichia coli fecal no patógena y factores asociados en leucemia infantil, SOLCA, Cuenca 2011

Abstract

Introduction: Escherichia coli fecal resistant is a risk to leukemia children health´s. The gut is a source germ´s and generates septicemias.

Objective: Characterizer Escherichia coli fecal non pathogen from children with leukemia and determinate the associate factors like: type of leukemia, neutropenia, antibiotic treatment, hospital stays, in SOLCA, Cuenca, 2011

Methodology: It was a transversal study, the universe were the children under 15 years old with leukemia diagnoses, the information gets of the institutional system´s. We establish sensibility or resistance with the CLSI guidelines. The bioethics committee approved this study. We used the EPIDAT program, descriptive statistics, square chi to statistic significance, prevalence reason’s with 95% IC to association.

Results: We estudied 55 isolates of Escherichia coli fecal, were resistant to Trimetoprim sulfametoxazol (50,9%), amoxicillin-clavulanate (30,9%), Ceftazidime (16,4%), Cefotaxime (16,4%), Ciprofloxacin (14,5), also Extended-Spectrum-β-Lactamases ESBL (10,9%). The neutropenia was associate to ESBL (p=0,01); the antibiotics intake was associate to ESBL (p=0,01). The hospital stay in the last month and six last months were associate to ESBL (p= 0,001). The ESBL was associate to ciprofloxacin resistance.

Conclusion: There was Escherichia coli fecal resistant to Trimetoprim sulfametoxazol, amoxicillin-clavulanate, Ceftazidime, cefotaxime, ciprofloxacin, also ESBL. The neutropenia, antibiotics intake and hospital stay are associate factors.

KEYWORDS: PREVALENCE, RESISTANCE, ESCHERICHIA COLI, Β-LACTAMASES