Validación del índice neutrófilo-linfocito como predictor de severidad en gestantes con trastornos hipertensivos, Hospital Vicente Corral Moscoso. Cuenca, 2020

Abstract

Background: gestational hypertensive disorders (GHD) are one of the main causes of maternal-perinatal morbidity and mortality worldwide, one of the three leading causes of maternal death in South America and the first in Ecuador. Objective: to evaluate the validity of the neutrophil/lymphocyte index as a predictor of severity in pregnant women with GHT in patients attended at the Gynecology and Obstetrics Service of the Vicente Corral Moscoso Regional Hospital during the year 2020. Methodological design: observational study of diagnostic test validation. There were 208 pregnant women with GHT who met the inclusion criteria. The neutrophil/lymphocyte index was contrasted with the clinical and laboratory diagnosis considered gold standard. Data collection was performed using a form developed by the author. Statistical analysis was performed with the SPSS v.26 program, determining the values of sensitivity (S), specificity (S) and positive predictive value (PPV), negative and ROC curve of the neutrophil/lymphocyte index p-value (0.000). Results: the probability of having a severe picture was associated with INL ≥ 3.785 OR: 5.67; 95% CI 2.36 - 13.63; p-value (0.000). INL ≥ 3.785, as prognostic for severe THG approached a regular prognostic accuracy (AUC = 0.7 - 0.75) and was statistically significant (p = 0.000), with an S = 53.8%; E = 82.9%; PPV = 91.7%; NPV = 34.0%. Conclusions: INL ≥ 3.785 has a fair prognostic accuracy for THG severity. Keywords: Validation Study. Disease Severity Index. Pregnancy Induced Hypertension.