Efecto del inmunoestimulante Yatren® Caseína en el tratamiento del tumor venéreo transmisible en pacientes caninos

Abstract

Transmissible venereal tumor (TVT) is a problem in countries with a considerable population of street dogs in the sexually active phase. In veterinary practice, there are several treatment options against TVT, including the application of immunotherapy. The objective of the research was to evaluate the effect of the immunostimulant Yatren® casein alone or in combination with a chemotherapeutic treatment (vincristine sulfate) on tumor regression in canine patients with TVT. This investigation was carried out in the veterinary clinics of the Santa Rosa and Machala cantons. For this purpose, a total of 24 canine patients diagnosed with TVT were randomly divided into 3 groups and treated with vincristine sulfate (n = 8), Yatren® casein (n = 8), and vincristine sulfate + Yatren® casein (n = 8), corresponding to treatments 1 (control), 2 and 3, respectively. The effect of the treatments evaluated: the macroscopic and histopathological changes produced in the tumors and the identification of alterations in the hematological and biochemical parameters that can be produced by each of the treatments under study. To evaluate the effect of the treatments under study, an Analysis of Variance (ANOVA) of repeated measures was used. Considering as statistically significant difference p<0.05. It was possible to determine that the immunostimulant Yatren® casein as a single drug against TVT is not significantly effective, however, the association of this immunostimulant with Vincristine Sulfate, a chemotherapeutic, produced a significant tumor regression when compared with the other two treatments and highly significant in the comparison between each week of their application. Regarding the presentation of side effects, changes at the macroscopic and histopathological level, no significant differences were found to be taken into consideration.