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Title:	Evaluation of injectable hyaluronic acid-based hydrogels for endodontic tissue regeneration
Authors:	Astudillo Ortiz, Esteban Andres Gomes, Manuela Reis, Rui Babo, Pedro
Keywords:	Hyaluronic acid Endodontic tissue regeneration Tissue engineering Injectable Hydrogels
metadata.dc.ucuenca.areaconocimientofrascatiamplio:	3. Ciencias Médicas y de la Salud
metadata.dc.ucuenca.areaconocimientofrascatidetallado:	3.2.15 Odontología
metadata.dc.ucuenca.areaconocimientofrascatiespecifico:	3.2 Medicina Clínica
metadata.dc.ucuenca.areaconocimientounescoamplio:	09 - Salud y Bienestar
metadata.dc.ucuenca.areaconocimientounescodetallado:	0911 - Estudios Dentales
metadata.dc.ucuenca.areaconocimientounescoespecifico:	091 - Salud
Issue Date:	2021
metadata.dc.ucuenca.volumen:	Volumen 14, número 23
metadata.dc.source:	Materials
metadata.dc.identifier.doi:	10.3390/ma14237325
metadata.dc.type:	ARTÍCULO
Description:	Dental pulp tissue engineering (TE) endeavors to regenerate dentin/pulp complex by combining a suitable supporting matrix, stem cells, and biochemical stimuli. Such procedures foresee a matrix that can be easily introduced into the root canal system (RCS) and tightly adhere to dentin walls to assure the dentin surface’s proper colonization with progenitor cells capable of restoring the dentin/pulp complex. Herein was investigated an injectable self-setting hyaluronic acid-based (HA) hydrogel system, formed by aldehyde-modified (a-HA) with hydrazide-modified (ADH), enriched with platelet lysate (PL), for endodontic regeneration. The hydrogels’ working (wT) and setting (sT) times, the adhesion to the dentine walls, the hydrogel’s microstructure, and the delivery of human dental pulp cells (DPCs) were studied in vitro. Hydrogels incorporating PL showed a suitable wT and sT and a porous microstructure. The tensile tests showed that the breaking point occurs after 4.3106 ± 1.8677 mm deformation, while in the indentation test after 1.4056 ± 0.3065 mm deformation. Both breaking points occur in the hydrogel extension. The HA/PL hydrogels exhibited supportive properties and promoted cell migration toward dentin surfaces in vitro. Overall, these results support using PL-laden HA injectable hydrogels (HA/PL) as a biomaterial for DPCs encapsulation, thereby displaying great clinical potential towards endodontic regenerative therapies.
URI:	http://dspace.ucuenca.edu.ec/handle/123456789/37916 https://www.scopus.com/record/display.uri?eid=2-s2.0-85120385764&origin=resultslist&sort=plf-f&src=s&st1=Evaluation+of+injectable+hyaluronic+acid-based+hydrogels+for+endodontic+tissue+regeneration&sid=e7b8595ddbab92f7a14f0199da6b766b&sot=b&sdt=b&sl=106&s=TITLE-ABS-KEY%28Evaluation+of+injectable+hyaluronic+acid-based+hydrogels+for+endodontic+tissue+regeneration%29&relpos=0&citeCnt=0&searchTerm=&retries=1
metadata.dc.ucuenca.urifuente:	https://www.mdpi.com/1996-1944/14/23
ISSN:	1996-1944
Appears in Collections:	Artículos

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