Interacciones medicamento–nutriente y medicamento–planta medicinal en el tratamiento farmacológico de la epilepsia con ácido valproico: revisión sistemática cualitativa

Abstract

BACKGROUND. The importance of studying drug-medicinal plant interactions lies at the critical point of being able to identify and prevent adverse effects in the future and at the same time modulate potential beneficial interactions.(1) In the United States, the Poison Control Center has reported nearly 200,000 hospital admissions due to the adverse drugs events. Psychiatric - drugs such as antidepressants, selective serotonin receptor inhibitors are responsible for 30.3% of cases, atypical antipsychotics 24.1% and other types of antidepressants 21.5% of them. (2) In this country, it has been reported that 20% of the population consumes herbal medicines with other medicines simultaneously and 70% of them do not report this information during consultation with their treating physician.(1)

GENERAL AIM. To synthesize the scientific evidence about the clinically relevant aspects of drug-nutrient and drug-medicinal plant interactions in the pharmacological treatment of epilepsy with valproic acid. METODOLOGY. Qualitative systematic review that analyzed articles of primary origin about reported interactions between valproic acid with nutrient / food or with medicinal plants. RESULTS. By applying the search equation and the search criteria, 909 articles were obtained, 12 studies were discarded, and the remaining 10 articles met the inclusion criteria. Of these, seven articles reported nutrient-drug interactions of pharmacokinetic type and one of them corresponds to medicinal plant-drug interaction. On the other hand, one reported a pharmacodynamics nutrient-drug interaction due to exacerbation of side effects related to liver dysfunction, and 2 articles reported absence of interaction.