Validación del fibrinógeno en la predicción de la fase apendicular en niños del Hospital Vicente Corral Moscoso, julio 2018 – junio 2019

Abstract

INTRUDUCTION: Acute appendicitis is one of the most frequent causes of abdominal pain in childhood, making it necessary to incorporate reliable diagnostic methods. Currently, fibrinogen is considered as an important test to identify the appendicular phase, as there are not scientific researches in pediatric patients of our community, the present study was developed. OBJECTIVE: To determine the diagnostic validity of fibrinogen in the prediction of the appendicular phase in children of the Pediatric Department of the Vicente Corral Moscoso Hospital (HVCM), 2018-2019. METHODS: Descriptive observational study of diagnostic test validation, a calculated consecutive sample of 127 patients was used, who were asked for fibrinogen as part of pre-surgical exams and pathological reports as a gold standard method; logistic regression analysis was performed to determine the association of this test with complicated appendicitis, establishing a cut-off point of its value using the ROC curve, determining its sensitivity, specificity, predictive values and probability coefficients. RESULTS: 55.9% had complicated appendicitis, the fibrinogen value found as the best cut-off point to predict this appendicular phase was 401.5mg/dl, with a sensitivity of 84.5% and a specificity of 80.4%. VPP 84.5%, NPV of 80.4%; CPP of 4.03 and CPN of 0.19. In addition, a statistically significant association (p = 0.000) was found, according to the area under the ROC curve, there is 87.9% (95% CI = 81.8 - 94.0%) of probability that an individual with complicated appendicitis have hyperfibrinogenemia. CONCLUSION: This study showed that fibrinogen is a good predictor to determine complicated acute appendicitis.