Hiperadrenocorticismo en perros (Canis lupus familiaris) y su relación con los cambios hematológicos y la presión arterial

Abstract

Hyperadrenocorticism, also called Cushing's Syndrome, is a severe multisystemic endocrinopathy characterized by elevated serum cortisol levels. This research aimed to analyze the relationship between hematological changes, urinary density, blood pressure and sexual condition in dogs with hyperadrenocorticism. Twentyfour dogs with this disease were analyzed (10 neutered and 14 non-neutered), who underwent a complete clinical examination and paraclinical tests such as: blood biochemistry, determination of specific urinary severity and measurement of blood pressure. The low dose dexamethasone suppression test was used to confirm the diagnosis of hyperadrenocorticism and high dose dexamethasone suppression to determine its origin. As a result, this disease modified the biochemical parameters and urinary density but there were no significant differences (p> 0.05) between the types of pituitary and adrenal hyperadrenocorticism (PDH and ADH) with respect to the aforementioned alterations. In the absence of a significant difference (p> 0.05), it was determined that the presence of the type of hyperadrenocorticism was independent of the patient's sexual condition (whole and neutered); however, significant differences (p <0.05) were found in cortisolemias in suppression with dexamethasone at high doses at 4 and 8 hours in relation to the type of hyperadrenocorticism, it was also significantly evidenced that dogs diagnosed with ADH (197 , 90 ± 11,066 mm Hg) are more hypertensive than PDH (158.28 ± 0.890 mm Hg). In conclusion, hyperadrenocorticism altered the biochemical parameters and that high-dose post-dexamethasone cortisol levels and blood pressure in ADH patients are increased with respect to PDH