Frecuencia de leucemia mieloide crónica en pacientes atendidos en el Instituto de Cáncer SOLCA de la ciudad de Cuenca durante el periodo 2012 – 2017. Cuenca 2019

Abstract

Chronic myeloid leukemia is a malignant hematologic malignancy that arises from the reciprocal translocation between chromosomes 9 and 22. It represents between 15 to 20% of all leukemias in adults and less than 5% in children and adolescents. Before the year 2000 the survival of chronic myeloid leukemia was less than 65%. GENERAL OBJECTIVE: To investigate the epidemiological characteristics of Chronic Myeloid Leukemia in patients treated at the Cancer Institute "SOLCA" of the city of Cuenca. METHODOLOGY: Design applied to all patients diagnosed with Chronic Myeloid Leukemia treated at the SOLCA Cancer Institute of Cuenca. The tabulation and analysis of the information was performed using the SPSS V23 test software and Microsoft EXCEL. Descriptive and quantitative statistics were used, which were represented by graphs and tables. RESULTS: Chronic myeloid leukemia between 2012 and 2017 was 12.7%, with a predominance of men (61.0%). The average age was 47.9 years, the mode 44 years, the minimum age 2 years and the maximum age 90 years. The origin with the highest number of cases corresponded to the province of Azuay with 61.0%, the most frequent occupation was household chores with 17.1%. And finally an 80.5% presence of the BCR / ABL fusion gene was established. CONCLUSIONS: CML is a disorder of chronic evolution that increases with age and its causative agent in 80.5% of cases is the BCR / ABL oncogene.