Logo Repositorio Institucional

Por favor, use este identificador para citar o enlazar este ítem: http://dspace.ucuenca.edu.ec/handle/123456789/33397
Título : Polyphenols and IUGR pregnancies: effects of maternal hydroxytyrosol supplementation on hepatic fat accretion and energy and fatty acids profile of fetal tissues
Autor: García Contreras, Consolación
Vazquez Gomez, Marta
Pardo, Zaira
Heras Molina, Ana
Pesantez Pacheco, Jose Luis
Encinas, Teresa
Torres Rovira, Laura
Astiz, Susana
Nieto, Rosa
Ovilo, Cristina
Gonzalez Bulnes, Antonio
Isabel, Beatriz
Correspondencia: Isabel Redondo, Beatriz, bisabelr@vet.ucm.es
Palabras clave : Antioxidants
Intrauterine-Growth-Restriction
Pregnancy
Swine-Model
Area de conocimiento FRASCATI amplio: 4. Ciencias Agrícolas
Area de conocimiento FRASCATI detallado: 4.2.2 Ganaderia: Mascotas
Area de conocimiento FRASCATI específico: 4.2 Zootecnia y Ciencia de los Lácteos
Area de conocimiento UNESCO amplio: 08 - Agricultura, Silvicultura, Pesca y Veterinaria
Area de conocimiento UNESCO detallado: 0841 - Veterinaria
Area de conocimiento UNESCO específico: 084 - Veterinaria
Fecha de publicación : 2019
Volumen: volumen 11, issue 7
Fuente: Nutrients
metadata.dc.identifier.doi: 10.3390/nu11071534
Tipo: ARTÍCULO
Abstract: 
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol, by preventing lipid peroxidation, may influence the fat accretion and energy homeostasis in the liver, as well as the fatty acid composition in the liver and muscle. The results indicate that hydroxytyrosol treatment significantly decreased the energy content of the fetal liver, without a ecting fat accretion, and caused significant changes in the availability of fatty acids. There were significant increases in the amount of total polyunsaturated fatty acids, omega-3 and omega-6, which are highly important for adequate fetal tissue development. However, there were increases in the omega-6/omega-3 ratio and the desaturation index, which make further studies necessary to determine possible e ects on the pro/anti-inflammatory status of the fetuses.
Resumen : 
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol, by preventing lipid peroxidation, may influence the fat accretion and energy homeostasis in the liver, as well as the fatty acid composition in the liver and muscle. The results indicate that hydroxytyrosol treatment significantly decreased the energy content of the fetal liver, without a ecting fat accretion, and caused significant changes in the availability of fatty acids. There were significant increases in the amount of total polyunsaturated fatty acids, omega-3 and omega-6, which are highly important for adequate fetal tissue development. However, there were increases in the omega-6/omega-3 ratio and the desaturation index, which make further studies necessary to determine possible e ects on the pro/anti-inflammatory status of the fetuses.
URI : http://dspace.ucuenca.edu.ec/handle/123456789/33397
https://www.ncbi.nlm.nih.gov/pubmed/31284510
URI Fuente: https://www.mdpi.com/journal/nutrients
ISSN : 2072-6643
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
documento.pdfdocument304.46 kBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está protegido por copyright original



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Centro de Documentacion Regional "Juan Bautista Vázquez"

Biblioteca Campus Central Biblioteca Campus Salud Biblioteca Campus Yanuncay
Av. 12 de Abril y Calle Agustín Cueva, Telf: 4051000 Ext. 1311, 1312, 1313, 1314. Horario de atención: Lunes-Viernes: 07H00-21H00. Sábados: 08H00-12H00 Av. El Paraíso 3-52, detrás del Hospital Regional "Vicente Corral Moscoso", Telf: 4051000 Ext. 3144. Horario de atención: Lunes-Viernes: 07H00-19H00 Av. 12 de Octubre y Diego de Tapia, antiguo Colegio Orientalista, Telf: 4051000 Ext. 3535 2810706 Ext. 116. Horario de atención: Lunes-Viernes: 07H30-19H00