Asociación genotípica y fenotípica del polimorfismo RS8192675 del transportador SIC2A2 con la hemoglobina glicosilada en pacientes con diabetes mellitus tipo 2 de la Fundación Donum

Abstract

The current study encompasses a non-experimental cross-sectional study, involving 102 individuals. The aim of the study was to carry out the genotypically and phenotypically association of the rs8192675 polymorphism of the SLC2A2 transporter with the Glycosylated Hemoglobin in patients with Type 2 Diabetes Mellitus at DONUM Foundation. The value of glycosylated hemoglobin was determined. Moreover, for the detection of polymorphism, Real Time PCR technique was used. The statistical analysis was performed with a confidence level of 95% and p<0.05. The presence of the polymorphism was found in four patients of the researched population and a genotypic and allelic frequency of 4% (n=4 and n=8 respectively). The results claim that there is no statistically significant relationship between the presence of the genetic variant and glycosylated hemoglobin levels. Additionally, in the association of the polymorphism with the compensation and decompensation status of patients, it was determined that there is no significant association between both parameters. Finally, the polymorphism did not prove to be a risky or protection factor.