Sobre-expresión de la proteína p 16 en biopsias con diagnóstico de NIC I, positivas para Genoma de Papiloma Virus Humano. Instituto del Cáncer. SOLCA Cuenca-Ecuador. 2009-2010.

Abstract

Numerous studies report that overexpression of p16 protein that is a biomarker to identify premalignant exocervical epithelium lesions would have a high association with human papillomavirus (HPV) with high oncogenic risk. It is a descriptive correlational study whose objective was to establish association of Cervical Intraepithelial Neoplasia grade I (CIN I), HPV positive, with the p16 expression. Materials, methods and results: It is a correlational study conducted from November 2009 to November 2010; about 256 cases of CIN I were presented, 72 were positive HPV; also p16 technique was performed. The women average age was 41 years. There were 40 (55.6%) positive cases for p16, and only 32 (44.4%) were negative. From the positive cases for p16, the most common viral types were high-risk patients: 33 (82.5%). The p16 was valued in amount, distribution and intensity, establishing a relationship between the intensity of p16 with high-risk virus (p = 0.038). When the age and viral type were analyzed, patients between 20 and 40 years (36 cases, 90%) presented HPV genome with high risk. Conclusions: There is correlation between the intensity of p16 with the presence of HPV high risk, helping select groups prone to disease progression.